Centre de Neurophysique, Physiologie et Pathologie - CNRS UMR 8119
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 20 80

Julien Grenier

Associate professor, MCU Université Paris Cité
Myelination and Nervous system pathologies

julien.grenier@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 38 87, room H330

More publications

RNA-Seq is not required to determine stable reference genes for qPCR normalization.

Sampathkumar NK, Sundaram VK, Danthi PS, Barakat R, Solomon S, Mondal M, Carre I, El Jalkh T, Padilla-Ferrer A, Grenier J, Massaad C, Mitchell JC.

Journal: PLoS Comput Biol.
Date: Février 2022
DOI: 10.1371/journal.pcbi.1009868
PMID: 35226660

Retracing Schwann Cell Developmental Transitions in Embryonic Dissociated DRG/Schwann Cell Cocultures in Mice.

Sundaram VK, El Jalkh T, Barakat R, Fernandez CJI, Massaad C, Grenier J.

Journal: Front Cell Neurosci.
Date: Mai 2021
DOI: 10.3389/fncel.2021.590537
PMID: 34093128

Corrigendum to “Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes”.

Shackleford G, Makoukji J, Grenier J, Liere P, Meffre D, Massaad C.

Journal: Biochem Pharmacol.
Date: Mai 2020
DOI: 10.1016/j.bcp.2020.113892
PMID: 32155468

GPR56/ADGRG1 is associated with response to antidepressant treatment.

Belzeaux R, Gorgievski V, Fiori LM, Lopez JP, Grenier J, Lin R, Nagy C, Ibrahim EC, Gascon E, Courtet P, Richard-Devantoy S, Berlim M, Chachamovich E, Théroux JF, Dumas S, Giros B, Rotzinger S, Soares CN, Foster JA, Mechawar N, Tall GG, Tzavara ET, Kennedy SH, Turecki G.

Journal: Nat Commun.
Date: Avril 2020
DOI: 10.1038/s41467-020-15423-5
PMID: 32242018

Targeting the NADPH Oxidase-4 and Liver X Receptor Pathway Preserves Schwann Cell Integrity in Diabetic Mice.

Eid SA, El Massry M, Hichor M, Haddad M, Grenier J, Dia B, Barakat R, Boutary S, Chanal J, Aractingi S, Wiesel P, Szyndralewiez C, Azar ST, Boitard C, Zaatari G, Eid AA, Massaad C.

Journal: Diabetes.
Date: Mars 2020
DOI: 10.2337/db19-0517
PMID: 31882567

Liver X Receptors and Their Implications in the Physiology and Pathology of the Peripheral Nervous System.

Sundaram VK, Massaad C, Grenier J.

Journal: Int J Mol Sci.
Date: Août 2019
DOI: 10.3390/ijms20174192
PMID: 31461876

Optimal use of statistical methods to validate reference gene stability in longitudinal studies.

Sundaram VK, Sampathkumar NK, Massaad C, Grenier J.

Journal: PLoS One.
Date: Juillet 2019
DOI: 10.1371/journal.pone.0219440
PMID: 31335863

Antidepressive effects of targeting ELK-1 signal transduction.

Apazoglou K, Farley S, Gorgievski V, Belzeaux R, Lopez JP, Grenier J, Ibrahim EC, El Khoury MA, Tse YC, Mongredien R, Barbé A, de Macedo CEA, Jaworski W, Bochereau A, Orrico A, Isingrini E, Guinaudie C, Mikasova L, Louis F, Gautron S, Groc L, Massaad C, Yildirim F, Vialou V, Dumas S, Marti F, Mechawar N, Morice E, Wong TP, Caboche J, Turecki G, Giros B, Tzavara ET.

Journal: Nat Med.
Date: Mai 2018
DOI: 10.1038/s41591-018-0011-0
PMID: 29736027

Liver X Receptor exerts a protective effect against the oxidative stress in the peripheral nerve.

Hichor M, Sundaram VK, Eid SA, Abdel-Rassoul R, Petit PX, Borderie D, Bastin J, Eid AA, Manuel M, Grenier J, Massaad C.

Journal: Sci Rep.
Date: Février 2018
DOI: 10.1038/s41598-018-20980-3
PMID: 29410501

Effect of physical exercise on brain and lipid metabolism in mouse models of multiple sclerosis.

Houdebine L, Gallelli CA, Rastelli M, Sampathkumar NK, Grenier J.

Journal: Chem Phys Lipids.
Date: Octobre 2017
DOI: 10.1016/j.chemphyslip.2017.06.002
PMID: 28606714

Paraquat Induces Peripheral Myelin Disruption and Locomotor Defects: Crosstalk with LXR and Wnt Pathways.

Hichor M, Sampathkumar NK, Montanaro J, Borderie D, Petit PX, Gorgievski V, Tzavara ET, Eid AA, Charbonnier F, Grenier J, Massaad C.

Journal: Antioxid Redox Signal.
Date: Juillet 2017
DOI: 10.1089/ars.2016.6711
PMID: 27788593

Liver X Receptors differentially modulate central myelin gene mRNA levels in a region-, age- and isoform-specific manner.

Shackleford GG, Grenier J, Abi Habib W, Massaad C, Meffre D.

Journal: J Steroid Biochem Mol Biol.
Date: Mai 2017
DOI: 10.1016/j.jsbmb.2016.02.032
PMID: 26940358

Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum.

Meffre D, Shackleford G, Hichor M, Gorgievski V, Tzavara ET, Trousson A, Ghoumari AM, Deboux C, Nait Oumesmar B, Liere P, Schumacher M, Baulieu EE, Charbonnier F, Grenier J, Massaad C.

Journal: Proc Natl Acad Sci U S A.
Date: Juin 2015
DOI: 10.1073/pnas.1424951112
PMID: 26023184

Wnt and lithium: a common destiny in the therapy of nervous system pathologies?

Meffre D, Grenier J, Bernard S, Courtin F, Dudev T, Shackleford G, Jafarian-Tehrani M, Massaad C.

Journal: Cell Mol Life Sci.
Date: Avril 2014
DOI: 10.1007/s00018-013-1378-1
PMID: 23749084

Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes.

Shackleford G, Makoukji J, Grenier J, Liere P, Meffre D, Massaad C.

Journal: Biochem Pharmacol.
Date: Juillet 2013
DOI: 10.1016/j.bcp.2013.02.036
PMID: 23500534

Lithium enhances remyelination of peripheral nerves.

Makoukji J, Belle M, Meffre D, Stassart R, Grenier J, Shackleford G, Fledrich R, Fonte C, Branchu J, Goulard M, de Waele C, Charbonnier F, Sereda MW, Baulieu EE, Schumacher M, Bernard S, Massaad C.

Journal: Proc Natl Acad Sci U S A.
Date: Mars 2012
DOI: 10.1073/pnas.1121367109
PMID: 22355115

Interplay between LXR and Wnt/β-catenin signaling in the negative regulation of peripheral myelin genes by oxysterols.

Makoukji J, Shackleford G, Meffre D, Grenier J, Liere P, Lobaccaro JM, Schumacher M, Massaad C.

Journal: J Neurosci.
Date: Juin 2011
DOI: 10.1523/JNEUROSCI.0761-11.2011
PMID: 21715627

Wnt/β-catenin signaling pathway is a direct enhancer of thyroid transcription factor-1 in human papillary thyroid carcinoma cells.

Gilbert-Sirieix M, Makoukji J, Kimura S, Talbot M, Caillou B, Massaad C, Massaad-Massade L.

Journal: PLoS One.
Date: Juillet 2011
DOI: 10.1371/journal.pone.0022280
PMID: 21814573

Cross-talk between oxysterols and glucocorticoids: differential regulation of secreted phospholipase A2 and impact on oligodendrocyte death.

Trousson A, Makoukji J, Petit PX, Bernard S, Slomianny C, Schumacher M, Massaad C.

Journal: PLoS One.
Date: Novembre 2009
DOI: 10.1371/journal.pone.0008080
PMID: 19956653

25-hydroxycholesterol provokes oligodendrocyte cell line apoptosis and stimulates the secreted phospholipase A2 type IIA via LXR beta and PXR.

Trousson A, Bernard S, Petit PX, Liere P, Pianos A, El Hadri K, Lobaccaro JM, Ghandour MS, Raymondjean M, Schumacher M, Massaad C.

Journal: J Neurochem.
Date: Mai 2009
DOI: 10.1111/j.1471-4159.2009.06009.x
PMID: 19250336

Relationship between neural crest cells and cranial mesoderm during head muscle development.

Grenier J, Teillet MA, Grifone R, Kelly RG, Duprez D.

Journal: PLoS One.
Date: Février 2009
DOI: 10.1371/journal.pone.0004381
PMID: 19198652

Properties of branchiomeric and somite-derived muscle development in Tbx1 mutant embryos.

Grifone R, Jarry T, Dandonneau M, Grenier J, Duprez D, Kelly RG.

Journal: Dev Dyn.
Date: Octobre 2008
DOI: 10.1002/dvdy.21718
PMID: 18816853

Recruitment of the p160 coactivators by the glucocorticoid receptor: dependence on the promoter context and cell type but not hypoxic conditions.

Trousson A, Grenier J, Fonte C, Massaad-Massade L, Schumacher M, Massaad C.

Journal: J Steroid Biochem Mol Biol.
Date: Mai 2007
DOI: 10.1016/j.jsbmb.2007.03.018
PMID: 17481888

Opposite effects of CBP and p300 in glucocorticoid signaling in astrocytes.

Fonte C, Trousson A, Grenier J, Schumacher M, Massaad C.

Journal: J Steroid Biochem Mol Biol.
Date: Mai 2007
DOI: 10.1016/j.jsbmb.2007.03.034
PMID: 17475479

Differential immunohistochemical and biological profile of squamous cell carcinoma of the breast.

Grenier J, Soria JC, Mathieu MC, Andre F, Abdelmoula S, Velasco V, Morat L, Besse B, Dunant A, Spielmann M, Delaloge S.

Journal: Anticancer Res.
Date: Janvier-Février 2007
PMID: 17348440

Differential recruitment of p160 coactivators by glucocorticoid receptor between Schwann cells and astrocytes.

Grenier J, Trousson A, Chauchereau A, Cartaud J, Schumacher M, Massaad C.

Journal: Mol Endocrinol.
Date: Février 2006
DOI: 10.1210/me.2005-0061
PMID: 16179382

[Unusual mechanism of action and assembly of the glucocorticoid receptor and its coactivators in glial cells].

Grenier J, Trousson A, Fonte C, Schumacher M, Massaad C.

Journal: Med Sci (Paris).
Date: Janvier 2006
DOI: 10.1051/medsci/200622116
PMID: 16386211

Identification by microarray analysis of aspartate aminotransferase and glutamine synthetase as glucocorticoid target genes in a mouse Schwann cell line.

Grenier J, Tomkiewicz C, Trousson A, Rajkowski KM, Schumacher M, Massaad C.

Journal: J Steroid Biochem Mol Biol.
Date: Décembre 2005
DOI: 10.1016/j.jsbmb.2005.06.034
PMID: 16182522

Involvement of {beta}-catenin and unusual behavior of CBP and p300 in glucocorticosteroid signaling in Schwann cells.

Fonte C, Grenier J, Trousson A, Chauchereau A, Lahuna O, Baulieu EE, Schumacher M, Massaad C.

Journal: Proc Natl Acad Sci U S A.
Date: Octobre 2005
DOI: 10.1073/pnas.0506930102
PMID: 16186500

Modulation of human mineralocorticoid receptor function by protein kinase A.

Massaad C, Houard N, Lombès M, Barouki R.

Journal: Mol Endocrinol.
Date: Janvier 1999
DOI: 10.1210/mend.13.1.0226
PMID: 9892012