Team 3 – Myelination and Nervous system pathologies

Despite the severe impact of the diseases of demyelination on patients’ lives and society, little is known about the processes of de/re/myelination. Our aim is to decipher the mechanisms of myelin physiology and pathologies affecting the nervous system. The main focuses are: (i) to identify new signaling pathways involved in myelination and demyelination; (ii) to examine their impact on nervous system pathologies (Multiple Sclerosis [MS], Nerve Injuries, Diabetic Peripheral Neuropathies [DPN], Traumatic Brain Injuries [TBI]); (iii) to study the impact of the environmental factors (stress, pollutants) on normal myelination process and on enhancing insults to cause exacerbated demyelination and co-morbidity; (iv) to develop alternative models to study interactions between peripheral myelin and nanoparticles by microfluidics.

We develop an interdisciplinary research based on preclinical and clinical approaches using molecular and cell biology, behavior, biophysics and physiology to study the myelination process as well as de/remyelination following pathological conditions. We focus our work on oxysterol/LXR, BDNF, and ADAM10 pathways as well as oxidative stress. Our project will allow deciphering the signaling pathways involved in myelination process and their dysregulation during demyelination. It will also open new avenues for the treatment of myelin pathologies.

Feel free to contact any our PI for internship, postdoctoral project and engineer / technician contract.

Permanent researchers

Céline Becker, Assistant Engineer, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Myelination and Nervous system pathologies
celine.becker@-Code to remove to avoid SPAM-inserm.fr, room H330
Christel Becker, Associate professor, MCU Université Paris Cité, Myelination and Nervous system pathologies
christel.becker@-Code to remove to avoid SPAM-u-paris.fr
Jean-Jacques Benoliel, Associate professor, MCU-PH Université Paris Cité, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Myelination and Nervous system pathologies
jean-jacques.benoliel@-Code to remove to avoid SPAM-upmc.fr, room H344
Sophie Bernard, University Professor, Myelination and Nervous system pathologies
sophie.bernard@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 20 46, room H344 A
Franck Brouillard, Associate professor, MCU Université Paris Cité, Myelination and Nervous system pathologies
franck.brouillard@-Code to remove to avoid SPAM-inserm.fr, room H344
Julien Grenier, Associate professor, MCU Université Paris Cité, Cell death in host-pathogen interactions, Myelination and Nervous system pathologies
julien.grenier@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 38 87, room H330
Mehrnaz Jafarian-Tehrani, University Professor, Myelination and Nervous system pathologies
mehrnaz.jafarian-tehrani@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 99 76, room H330
Damien Le Menuet, INSERM researcher, CR- INSERM, Myelination and Nervous system pathologies
damien.le-menuet@-Code to remove to avoid SPAM-inserm.fr, +33 1 70 64 99 76, room H330
Charbel Massaad, university Professor, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Myelination and Nervous system pathologies
charbel.massaad@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 22 22, room P410
Delphine Meffre, Associate professor, MCU Université Paris Cité, Europe department, Myelination and Nervous system pathologies
delphine.meffre@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 22 73, room H344
Hugo Salmon, Assistant Professor, Cell death in host-pathogen interactions, Myelination and Nervous system pathologies
hugo.salmon@-Code to remove to avoid SPAM-u-paris.fr

Support staff

Sara FALGHERA, Engineer, Myelination and Nervous system pathologies
Anne Simon, Engineer, Myelination and Nervous system pathologies
anne.simon@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 21 53 or 38 87, room H330

Post docs and PhD students

Pilar ACEBO, PhD student, Myelination and Nervous system pathologies
Mathis LAVAUD, PhD student, Myelination and Nervous system pathologies

Journal articles

2024

ref_biblio
Solène Moreau, Raul Flores-Berdines, Tatiana El Jalkh, Anne Simon, Guillaume Taret, et al.. Reversible and reusable compartmentalized microfluidic chip for coculture of dorsal root ganglion neurons. Bioarxiv, 2024, ⟨10.1101/2024.12.10.627139⟩. ⟨hal-04987043⟩

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Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehrani. A Disintegrin And Metalloprotease 10 expression within the murine central nervous system. Brain Research, 2024, 1834, pp.148888. ⟨10.1016/j.brainres.2024.148888⟩. ⟨hal-04595759⟩

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2023

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Alberto González-Mayoral, Axel Eid, Razmig Derounian, Virginia Sofia Campanella, Andreia da Silva Ramos, et al.. Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness. Journal of Endocrinology, 2023, 258 (2), pp.e220334. ⟨10.1530/JOE-22-0334⟩. ⟨inserm-04163081⟩

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2022

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Guy Khalaf, Claudia Mattern, Mélina Begou, Odile Boespflug-Tanguy, Charbel Massaad, et al.. Mutation of Proteolipid Protein 1 Gene: From Severe Hypomyelinating Leukodystrophy to Inherited Spastic Paraplegia. Biomedicines, 2022, 10 (7), pp.1709. ⟨10.3390/biomedicines10071709⟩. ⟨hal-03798606⟩

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Max Piffoux, Amanda Silva, Florence Gazeau, Hugo Salmon. Potential of on‐chip analysis and engineering techniques for extracellular vesicle bioproduction for therapeutics. Re View, 2022, 3 (1), pp.20200175. ⟨10.1002/VIW.20200175⟩. ⟨hal-03868884⟩

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2021

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Jérémie Canonica, Min Zhao, Tatiana Favez, Emmanuelle Gelizé, Laurent Jonet, et al.. Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium. International Journal of Molecular Sciences, 2021, 22 (17), pp.9618. ⟨10.3390/ijms22179618⟩. ⟨hal-03353932⟩

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Alex Carrete, Aïda Padilla-Ferrer, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehrani. Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis. Neuroscience, 2021, 455, pp.240-250. ⟨10.1016/j.neuroscience.2020.11.027⟩. ⟨hal-04914549⟩

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Hugo Salmon, M. Reza Rasouli, Nicholas Distasio, Maryam Tabrizian. Facile engineering and interfacing of styrenic block copolymers devices for low‐cost, multipurpose microfluidic applications. Engineering Reports, 2021, 3 (7), pp.479. ⟨10.1002/eng2.12361⟩. ⟨hal-04987048⟩

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2020

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Elena Chierto, Giulia Cristinziano, Francesca Sapone, Delphine Meffre, Mehrnaz Jafarian-Tehrani. Effect of Etazolate on ROS Production after tBHP-Induced Oxidative Stress in Oligodendroglial 158N Cell Line. Reactive Oxygen Species, 2020, ⟨10.20455/ros.2020.807⟩. ⟨hal-04914200⟩

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Nicholas Distasio, Hugo Salmon, France Dierick, Talin Ebrahimian, Maryam Tabrizian, et al.. VCAM‐1‐Targeted Gene Delivery Nanoparticles Localize to Inflamed Endothelial Cells and Atherosclerotic Plaques. Advanced Therapeutics, 2020, 4 (2), ⟨10.1002/adtp.202000196⟩. ⟨hal-04987052⟩

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2019

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Hui Chen, Larbi Amazit, Marc Lombès, Damien Le Menuet. Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression. Neuroscience, 2019, 399, pp.12-27. ⟨10.1016/j.neuroscience.2018.12.012⟩. ⟨inserm-02298752⟩

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Emmanuelle Kuhn, Khadija Lamribet, Say Viengchareun, Damien Le Menuet, Bruno Fève, et al.. UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects. Annales d'Endocrinologie = Annals of Endocrinology, 2019, 80 (1), pp.1-9. ⟨10.1016/j.ando.2018.04.018⟩. ⟨hal-02189371⟩

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Gemma Llufriu-Dabén, Delphine Meffre, Charbel Massaad, Mehrnaz Jafarian-Tehrani. A novel model of trauma-induced cerebellar injury and myelin loss in mouse organotypic cerebellar slice cultures using live imaging. Journal of Neuroscience Methods, 2019, 311, pp.385-393. ⟨10.1016/j.jneumeth.2018.09.023⟩. ⟨hal-04914348⟩

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Hugo Salmon, Rabah Gahoual, Pascal Houzé, Tayssir Ibrahim, Michel Bessodes, et al.. Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics. Nanomedicine: Nanotechnology, Biology and Medicine, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩. ⟨hal-02123126⟩

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Hugo Salmon, Christophe Roblin, Laurent Couraud, Gilgueng Hwang. Microrobot-in-glass for dynamic motion analysis and wider in vitro applications. Micro and Nano Letters, 2019, ⟨10.1049/mnl.2019.0006⟩. ⟨hal-02087207⟩

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Hugo Salmon, Laurent Couraud, Gilgueng Hwang. On-chip mobile microrobotic transducer for high-temporal resolution sensing using dynamics analysis. Sensors and Actuators A: Physical , 2019, 288, pp.27-38. ⟨10.1016/j.sna.2018.12.043⟩. ⟨hal-02087217⟩

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2018

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Elena Chierto, Anne Simon, Francesca Castoldi, Delphine Meffre, Giulia Cristinziano, et al.. Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes. Molecular Neurobiology, 2018, 56 (6), pp.4231-4248. ⟨10.1007/s12035-018-1372-6⟩. ⟨hal-04914110⟩

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Julie Lachaux, Hugo Salmon, Fanny Loisel, Nassim Arouche, Ignacio Ochoa, et al.. Soft Thermoplastic Elastomer for Easy and Rapid Spin‐Coating Fabrication of Microfluidic Devices with High Hydrophilization and Bonding Performances. Advanced Materials Technologies, 2018, 4 (2), ⟨10.1002/admt.201800308⟩. ⟨hal-04526639⟩

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Gemma Llufriu-Dabén, Alex Carrete, Elena Chierto, Jo Mailleux, Emeline Camand, et al.. Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system. Neurobiology of Disease, 2018, 109, pp.11-24. ⟨10.1016/j.nbd.2017.09.008⟩. ⟨hal-04914461⟩

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Ghjuvan Ghjacumu Shackleford, Nirmal Kumar Sampathkumar, Mehdi Hichor, Laure Weill, Delphine Meffre, et al.. The Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (6), pp.E1319-E1328. ⟨10.1073/pnas.1715999115⟩. ⟨hal-02110942⟩

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2017

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Hui Chen, Marc Lombès, Damien Le Menuet. Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells. Molecular Brain, 2017, 10 (1), pp.12. ⟨10.1186/s13041-017-0295-x⟩. ⟨inserm-02329880⟩

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Gérard Lizard, Charbel Massaad, Luigi Iuliano. Oxysterols and phytosterols in human health. Chemistry and Physics of Lipids, 2017, Epub ahead of print. ⟨10.1016/j.chemphyslip.2017.08.005⟩. ⟨inserm-01590603⟩

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Ghjuvan’ Ghjacumu Shackleford, Julien Grenier, Walid Abi Habib, Charbel Massaad, Delphine Meffre. Liver X Receptors differentially modulate central myelin gene mRNA levels in a region-, age- and isoform-specific manner. Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.61-68. ⟨10.1016/j.jsbmb.2016.02.032⟩. ⟨hal-04914447⟩

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2015

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Delphine Meffre, Ghjuvan'Ghjacumu Shackleford, Mehdi Hichor, Victor Gorgievski, Eleni T. Tzavara, et al.. Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (24), pp.7587-7592. ⟨10.1073/pnas.1424951112⟩. ⟨hal-01542311⟩

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D. Meffre, C. Massaad, J. Grenier. Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/β-catenin and Akt/CREB pathways. Neuroscience, 2015, 284, pp.962-971. ⟨10.1016/j.neuroscience.2014.10.064⟩. ⟨hal-04914441⟩

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Delphine Meffre, Ghjuvan’ghjacumu Shackleford, Mehdi Hichor, Victor Gorgievski, Eleni Tzavara, et al.. Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (24), pp.7587-7592. ⟨10.1073/pnas.1424951112⟩. ⟨hal-04516570⟩

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Fausto Ulloa, Alba Gonzàlez-Juncà, Delphine Meffre, Pablo José Barrecheguren, Ramón Martínez-Mármol, et al.. Blockade of the SNARE Protein Syntaxin 1 Inhibits Glioblastoma Tumor Growth. PLoS ONE, 2015, 10 (3), pp.e0119707. ⟨10.1371/journal.pone.0119707⟩. ⟨hal-04914419⟩

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2014

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Gilgueng Hwang, Ioan Alexandru Ivan, Joël Agnus, Hugo Salmon, Sébastien Alvo, et al.. Mobile microrobotic manipulator in microfluidics. Sensors and Actuators A: Physical , 2014, 215, pp.56-64. ⟨10.1016/j.sna.2013.09.030⟩. ⟨hal-02087263⟩

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Emmanuelle Kuhn, Christine Bourgeois, Vixra Keo, Say Viengchareun, Adeline Muscat, et al.. Paradoxical resistance to high fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor overexpressing mice.. AJP - Endocrinology and Metabolism, 2014, 306 (1), pp.E75-90. ⟨10.1152/ajpendo.00323.2013⟩. ⟨inserm-00911857⟩

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2013

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Laetitia Martinerie, Mathilde Munier, Damien Le Menuet, Geri Meduri, Say Viengchareun, et al.. The mineralocorticoid signaling pathway throughout development: Expression, regulation and pathophysiological implications. Biochimie, 2013, 95 (2), pp.148-157. ⟨10.1016/j.biochi.2012.09.030⟩. ⟨hal-02955448⟩

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D. Meffre, F. Labombarda, B. Delespierre, A. Chastre, A.F. de Nicola, et al.. Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury. Neuroscience, 2013, 231, pp.111-124. ⟨10.1016/j.neuroscience.2012.11.039⟩. ⟨hal-04914379⟩

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2012

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Damien Le Menuet, Mathilde Munier, Giulia Campostrini, Marc Lombès. Mineralocorticoid receptor and embryonic stem cell models: Molecular insights and pathophysiological relevance. Molecular and Cellular Endocrinology, 2012, 350 (2), pp.216-222. ⟨10.1016/j.mce.2011.06.036⟩. ⟨hal-02955447⟩

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Joelle Makoukji, Martin Belle, Delphine Meffre, Ruth Stassart, Julien Grenier, et al.. Lithium enhances remyelination of peripheral nerves. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (10), pp.3973-3978. ⟨10.1073/pnas.1121367109⟩. ⟨hal-04914360⟩

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Mathilde Munier, Fredéric Law, Géri Meduri, Damien Le Menuet, Marc Lombes. Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons.. Endocrinology, 2012, 153 (3), pp.1330-40. ⟨10.1210/en.2011-1436⟩. ⟨inserm-00654278⟩

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2010

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F. Labombarda, D. Meffre, B. Delespierre, S. Krivokapic-Blondiaux, A. Chastre, et al.. Membrane progesterone receptors localization in the mouse spinal cord. Neuroscience, 2010, 166 (1), pp.94-106. ⟨10.1016/j.neuroscience.2009.12.012⟩. ⟨hal-04914343⟩

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Damien Le Menuet, Mathilde Munier, Géri Meduri, Say Viengchareun, Marc Lombès. Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.. Cardiovascular Research, 2010, 87 (3), pp.467-75. ⟨10.1093/cvr/cvq087⟩. ⟨inserm-00463814⟩

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ref_biblio
Mathilde Munier, Geri Meduri, Say Viengchareun, Phillipe Leclerc, Damien Le Menuet, et al.. Regulation of mineralocorticoid receptor expression during neuronal differentiation of murine embryonic stem cells.. Endocrinology, 2010, 151 (5), pp.2244-54. ⟨10.1210/en.2009-0753⟩. ⟨inserm-00450814⟩

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2008

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R. Guennoun, Delphine Meffre, F. Labombarda, S.L. Gonzalez, M.C. Gonzalez Deniselle, et al.. The membrane-associated progesterone-binding protein 25-Dx: Expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Research Reviews, 2008, 57 (2), pp.493-505. ⟨10.1016/j.brainresrev.2007.05.009⟩. ⟨hal-04914608⟩

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2007

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D. Meffre, A. Pianos, P. Liere, B. Eychenne, A. Cambourg, et al.. Steroid Profiling in Brain and Plasma of Male and Pseudopregnant Female Rats after Traumatic Brain Injury: Analysis by Gas Chromatography/Mass Spectrometry. Endocrinology, 2007, 148 (5), pp.2505-2517. ⟨10.1210/en.2006-1678⟩. ⟨hal-04914383⟩

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Delphine Meffre, Brigitte Delespierre, Monique Gouézou, Michael Schumacher, Donald Stein, et al.. 3β-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: Effect of pseudopregnancy and traumatic brain injury. Journal of Steroid Biochemistry and Molecular Biology, 2007, 104 (3-5), pp.293-300. ⟨10.1016/j.jsbmb.2007.03.003⟩. ⟨hal-04914390⟩

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Say Viengchareun, Damien Le Menuet, Laetitia Martinerie, Mathilde Munier, Laurent Pascual-Le Tallec, et al.. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.. Nuclear Receptor Signaling, 2007, 5, pp.e012. ⟨10.1621/nrs.05012⟩. ⟨inserm-00193515⟩

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2005

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Delphine Meffre, Brigitte Delespierre, Monique Gouézou, Philippe Leclerc, Gavin Vinson, et al.. The membrane‐associated progesterone‐binding protein 25‐Dx is expressed in brain regions involved in water homeostasis and is up‐regulated after traumatic brain injury. Journal of Neurochemistry, 2005, 93 (5), pp.1314-1326. ⟨10.1111/j.1471-4159.2005.03127.x⟩. ⟨hal-04914385⟩

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Conference papers

2013

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Gilgueng Hwang, Hugo Salmon, Loan Alexandra Ivan, Joël Agnus, Nicolas Chaillet, et al.. Large range versatile wireless microrobotic manipulators in microfluidic devices. 2013 IEEE 26th International Conference on Micro Electro Mechanical Systems (MEMS), Jan 2013, Taipei, France. pp.1179-1182, ⟨10.1109/MEMSYS.2013.6474462⟩. ⟨hal-02087246⟩

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Hugo Salmon, Laurent Couraud, Gilgueng Hwang. Using breakdown phenomenon as mobile magnetic field sensor in microfluidics. 2013 IEEE/RSJ International Conference on Intelligent Robots and Systems (IROS 2013), Nov 2013, Tokyo, France. pp.2041-2046, ⟨10.1109/IROS.2013.6696629⟩. ⟨hal-02087218⟩

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Hugo Salmon, Laurent Couraud, Gilgueng Hwang. Swimming property characterizations of Magnetic Polarizable microrobots. 2013 IEEE International Conference on Robotics and Automation (ICRA), May 2013, Karlsruhe, Germany. pp.5520-5526, ⟨10.1109/ICRA.2013.6631369⟩. ⟨hal-02087219⟩

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Dictionary entry

2013

ref_biblio
Delphine Meffre, Julien Grenier, Sophie Bernard, Françoise Courtin, Todor Dudev, et al.. Wnt and lithium: a common destiny in the therapy of nervous system pathologies?. Wnt and lithium: a common destiny in the therapy of nervous system pathologies?, 2013, pp.1123-1148. ⟨10.1007/s00018-013-1378-1⟩. ⟨hal-04914401⟩

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Ghjuvan’ghjacumu Shackleford, Joelle Makoukji, Julien Grenier, Philippe Liere, Delphine Meffre, et al.. Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes. Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes, 2013, pp.106-114. ⟨10.1016/j.bcp.2013.02.036⟩. ⟨hal-04914456⟩

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Theses

2014

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Hugo Salmon. Mobile Magnetic Microrobots Control and Study in Microfluidic Environment : New Tools for Biomedical Applications. Other [cond-mat.other]. Université Paris Sud - Paris XI, 2014. English. ⟨NNT : 2014PA112266⟩. ⟨tel-04574954⟩

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