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Centre de Neurophysique, Physiologie et Pathologie - CNRS UMR 8119
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 20 80

Dr. Florence Noble

CNRS researcher, DR-CNRS
Pharmacology and Addiction Therapies

florence.noble@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 38 89, room H436

Journal articles

2023

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Nicolas Marie, Florence Noble. Oxycodone, an opioid like the others?. Frontiers in Psychiatry, 2023, 14, pp.1229439. ⟨10.3389/fpsyt.2023.1229439⟩. ⟨hal-04767364⟩
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https://hal.science/hal-04767364/file/Marie%20et%20Noble%20-%202023%20-%20Oxycodone%2C%20an%20opioid%20like%20the%20others.pdf BibTex

2021

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Candice Marion, Philippe Zizzari, Raphael G P Denis, Rim Hassouna, Yacine Chebani, et al.. The GhsrQ343X allele favors the storage of fat by acting on nutrient partitioning. Journal of Endocrinology, 2021, pp.JOE-20-0576.R2. ⟨10.1530/JOE-20-0576⟩. ⟨inserm-03365851v2⟩
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https://inserm.hal.science/inserm-03365851/file/Marion%20et%20al%202021_Author%27s%20copy.pdf BibTex

2020

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Jérôme Busserolles, Ismail Ben Soussia, Laetitia Pouchol, Nicolas Marie, Mathieu Meleine, et al.. TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects. British Journal of Pharmacology, 2020, 177 (20), pp.4782-4795. ⟨10.1111/bph.15243⟩. ⟨hal-03512213⟩
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https://uca.hal.science/hal-03512213/file/BPH-177-4782.pdf BibTex

2019

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Hélène Geoffroy, Corinne Canestrelli, Nicolas Marie, Florence Noble. Morphine-Induced Dendritic Spine Remodeling in Rat Nucleus Accumbens Is Corticosterone Dependent. International Journal of Neuropsychopharmacology, 2019, 22 (6), pp.394-401. ⟨10.1093/ijnp/pyz014⟩. ⟨hal-02147545⟩
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https://hal.science/hal-02147545/file/main.pdf BibTex
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Nicolas Marie, Corinne Canestrelli, Florence Noble. Role of pharmacokinetic and pharmacodynamic parameters in neuroadaptations induced by drugs of abuse, with a focus on opioids and psychostimulants. Neuroscience and Biobehavioral Reviews, 2019, 106, pp.217-226. ⟨10.1016/j.neubiorev.2018.06.006⟩. ⟨hal-02147556⟩
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https://hal.science/hal-02147556/file/1-s2.0-S0149763418300204-am.pdf BibTex
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Florence Noble, Nicolas Marie. Management of Opioid Addiction With Opioid Substitution Treatments: Beyond Methadone and Buprenorphine. Frontiers in Psychiatry, 2019, 9, pp.742. ⟨10.3389/fpsyt.2018.00742⟩. ⟨hal-02147550⟩
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https://hal.science/hal-02147550/file/main.pdf BibTex

2018

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Zuzana Hajasova, Corinne Canestrelli, Francine Acher, Florence Noble, Nicolas Marie. Role of mGlu7 receptor in morphine rewarding effects is uncovered by a novel orthosteric agonist. Neuropharmacology, 2018, 131, pp.424-430. ⟨10.1016/j.neuropharm.2018.01.002⟩. ⟨hal-02147571⟩
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Sophie Lebourgeois, Catherine Vilpoux, Jérôme Jeanblanc, Francine Acher, Nicolas Marie, et al.. Pharmacological activation of mGlu4 and mGlu7 receptors, by LSP2-9166, reduces ethanol consumption and relapse in rat. Neuropharmacology, 2018, 133, pp.163-170. ⟨10.1016/j.neuropharm.2018.01.031⟩. ⟨hal-02147563⟩
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2016

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Magalie Lenoir, Florence Noble. Qu’apporte la neurobiologie aux addictions ?. La Presse Médicale, 2016, 45 (12), pp.1096-1101. ⟨10.1016/j.lpm.2016.02.021⟩. ⟨hal-02347858⟩
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Luca Posa, Alison Accarie, Florence Noble, Nicolas Marie. Methadone Reverses Analgesic Tolerance Induced by Morphine Pretreatment. International Journal of Neuropsychopharmacology, 2016, 19 (7), pyv108. ⟨10.1093/ijnp/pyv108⟩. ⟨hal-02147576⟩
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https://hal.science/hal-02147576/file/main.pdf BibTex

2015

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Stéphane Allouche, Thierry Le Marec, Antoine Coquerel, Florence Noble, Nicolas Marie. Striatal dopamine D1 and D2 receptors are differentially regulated following buprenorphine or methadone treatment. Psychopharmacology, 2015, 232 (9), pp.1527-1533. ⟨10.1007/s00213-014-3785-x⟩. ⟨hal-02147637⟩
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Sandrine Geoffroy, Stéphanie Puig, Nadia Benturquia, Florence Noble. Temporal Regulation of Peripheral BDNF Levels during Cocaine and Morphine Withdrawal: Comparison with a Natural Reward. International Journal of Neuropsychopharmacology, 2015, 18 (5), pyu088 - pyu088. ⟨10.1093/ijnp/pyu088⟩. ⟨hal-01899919⟩
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Florence Noble, Magalie Lenoir, Nicolas Marie. The opioid receptors as targets for drug abuse medication. British Journal of Pharmacology, 2015, 172 (16), pp.3964-3979. ⟨10.1111/bph.13190⟩. ⟨hal-02147631⟩
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2014

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Stephane Allouche, Florence Noble, Nicolas Marie. Opioid receptor desensitization: mechanisms and its link to tolerance. Frontiers in Pharmacology, 2014, 5, pp.280. ⟨10.3389/fphar.2014.00280⟩. ⟨hal-02149861⟩
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https://hal.science/hal-02149861/file/main.pdf BibTex
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Corinne Canestrelli, Nicolas Marie, Florence Noble. Rewarding or aversive effects of buprenorphine/naloxone combination (Suboxone) depend on conditioning trial duration. International Journal of Neuropsychopharmacology, 2014, 17 (09), pp.1367-1373. ⟨10.1017/S146114571400025X⟩. ⟨hal-02154084⟩
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https://hal.science/hal-02154084/file/17-9-1367.pdf BibTex
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Maria Seleman, Hélène Chapy, Salvatore Cisternino, Cindie Courtin, Maria Smirnova, et al.. Impact of P-glycoprotein at the blood-brain barrier on the uptake of heroin and its main metabolites: behavioral effects and consequences on the transcriptional responses and reinforcing properties. Psychopharmacology, 2014, 231 (16), pp.3139 - 3149. ⟨10.1007/s00213-014-3490-9⟩. ⟨hal-01904771⟩
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https://hal.science/hal-01904771/file/Seleman%20et%20al%202014.pdf BibTex

2013

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Stéphane Allouche, Thierry Le Marec, Florence Noble, Nicolas Marie. Different patterns of administration modulate propensity of methadone and buprenorphine to promote locomotor sensitization in mice. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013, 40, pp.286-291. ⟨10.1016/j.pnpbp.2012.10.013⟩. ⟨hal-02154116⟩
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2012

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Stéphanie Puig, Florence Noble, Nadia Benturquia. Short- and long-lasting behavioral and neurochemical adaptations: relationship with patterns of cocaine administration and expectation of drug effects in rats. Translational Psychiatry, 2012, 2 (10), pp.e175 - e175. ⟨10.1038/tp.2012.103⟩. ⟨hal-01899921⟩
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2011

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Cynthia Marie-Claire, Thierry Le Marec, Cynthia Marie, Florence Noble, Nicolas Marie. Chronic and intermittent morphine treatment differently regulates opioid and dopamine systems: a role in locomotor sensitization. Psychopharmacology, 2011, 216 (2), pp.297 - 303. ⟨10.1007/s00213-011-2223-6⟩. ⟨hal-01905192⟩
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2008

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Stephane Desjardins, Emilie Belkai, Dominique Crete, Laurie Cordonnier, Jean-Michel Scherrmann, et al.. Effects of chronic morphine and morphine withdrawal on gene expression in rat peripheral blood mononuclear cells. Neuropharmacology, 2008, 55 (8), pp.1347 - 1354. ⟨10.1016/j.neuropharm.2008.08.027⟩. ⟨hal-01905201⟩
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Sabah Kelai, Gilles Maussion, Florence Noble, Claudette Boni, Nicolas Ramoz, et al.. Nrxn3 upregulation in the globus pallidus of mice developing cocaine addiction.. NeuroReport, 2008, 19 (7), pp.751-5. ⟨10.1097/WNR.0b013e3282fda231⟩. ⟨inserm-00320209⟩
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https://inserm.hal.science/inserm-00320209/file/Kelai_et_al_2008.pdf BibTex

2004

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Cynthia Marie-Claire, Cindie Courtin, Bernard P. Roques, Florence Noble. Cytoskeletal genes regulation by chronic morphine treatment in rat striatum.. Neuropsychopharmacology, 2004, 29 (12), pp.2208-15. ⟨10.1038/sj.npp.1300513⟩. ⟨inserm-00144800⟩
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https://inserm.hal.science/inserm-00144800/file/marie-claire_et_al.pdf BibTex

1997

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Bruno Bellier, Isabelle Mccort, Bertrand Ducos, Sophie Danascimento, Hervé Meudal, et al.. Synthesis and Biological Properties of New Constrained CCK-B Antagonists: Discrimination of Two Affinity States of the CCK-B Receptor on Transfected CHO Cells. Journal of Medicinal Chemistry, 1997, 40 (24), pp.3947-3956. ⟨10.1021/jm970439a⟩. ⟨hal-02122116⟩
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Florence Noble, Claire Smadja, Olga Valverde, Rafael Maldonado, Pascale Coric, et al.. Pain-suppressive effects on various nociceptive stimuli (thermal, chemical, electrical and inflammatory) of the first orally active enkephalin-metabolizing enzyme inhibitor RB 120. Pain, 1997, 73 (3), pp.383-391. ⟨10.1016/S0304-3959(97)00125-5⟩. ⟨hal-02461424⟩
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1994

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Florence Noble, Pascale Coric, Serge Turcaud, Marie-Claude Fournie-Zaluski, Bernard P. Roques. Assessment of physical dependence after continuous perfusion into the rat jugular vein of the mixed inhibitor of enkephalin-degrading enzymes, RB 101. European Journal of Pharmacology, 1994, 253 (3), pp.283-287. ⟨10.1016/0014-2999(94)90203-8⟩. ⟨hal-02461489⟩
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1992

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Marie Claude Fournie-Zaluski, Pascal Coric, Serge Turcaud, Evelyne Lucas, Florence Noble, et al.. Mixed-inhibitor-prodrug as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes. Journal of Medicinal Chemistry, 1992, 35 (13), pp.2473-2481. ⟨10.1021/jm00091a016⟩. ⟨hal-02461535⟩
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Marie Claude Fournie-Zaluski, Pascale Coric, Serge Turcaud, Luce Bruetschy, Evelyne Lucas, et al.. Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation. Journal of Medicinal Chemistry, 1992, 35 (7), pp.1259-1266. ⟨10.1021/jm00085a013⟩. ⟨hal-02461529⟩
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Florence Noble, Pascale Coric, Marie-Claude Fournie-Zaluski, Bernard P. Roques. Lack of physical dependence in mice after repeated systemic administration of the mixed inhibitor prodrug of enkephalin-degrading enzymes, RB101. European Journal of Pharmacology, 1992, 223 (1), pp.91-96. ⟨10.1016/0014-2999(92)90822-L⟩. ⟨hal-02461500⟩
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Reports

2012

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Agnès Cadet-Taïrou, Tiphaine Canarelli, Serge Escots, Françoise Facy, Laurence Lanfumey-Mongredien, et al.. Médicaments psychotropes : Consommations et pharmacodépendances. [Rapport de recherche] Institut national de la santé et de la recherche médicale(INSERM). 2012, Paris : Inserm : Éditions EDP Sciences (ISSN : 1264-1782) / 598 p. ⟨inserm-02102985⟩
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https://inserm.hal.science/inserm-02102985/file/Inserm_EC_2012_MedicamentsPsychotropesConsommationsPharmacodependances_Synthese.pdf BibTex

Preprints, Working Papers, ...

2021

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Magalie Lenoir, Isabella Bondi, Loïc Clemenceau, Isabelle Nondier, Margaux Ballé, et al.. Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation. 2021. ⟨hal-03365414⟩
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