Hugo Salmon

Myelination and Nervous system pathologies and Physics advanced instrument (NABI)

Education

Engineer from Ecole Centrale de Lille, agrégé in Mathematics PhD in physics from Université Paris Saclay.

Research interests

• Thermoplastic microfluidics for analytical and organ on chip applications
• Modeling myelination, demyelination and remyelination processes in microphysiological sytems
• Extracellular vesicles interaction with myelin (transport, phenotyping and potency tests)
• Analytical techniques for physicochemical characterization of nanoparticles

Teaching

Mechanics, thermodynamics, microphysiological systems, mathematical modeling, design and fabrication, statistics, project management, improv.

Staff of the international Master’s program in Biomedical engineering

Contact

Idhal: hugosalmon
ORCID: 0000-0002-5486-1370 Profil Google scholar

Myelin on chip and the study of EV in the context of myelin

Myelin is a complex system at multiple levels: bioelectrical, biomechanical and biochemical. There are currently no therapeutic to cure demyelinating diseases. The lack of simple model complicates the screening of drug therapeutics (Moreau et al 2025, review). Our group develop compartmentalized on-chip model (Moreau. et al 2025, research article) to facilitate the screening of therapeutics and study the role of extracellular vesicles in the remyelination / demyelination processes.

Asymmetrical field flow fraction for nanobiotherapeutics: development of tailored method and miniaturization of the device

Nanomedicines and nanobiotherapeutics offer better targeting and more efficient drug delivery, enhancing therapeutic outcomes while minimizing side effects. Yet, they also complexify the formulation and interaction with biological systems, as function of their size distribution, shape and surface properties. Asymmetrical flow field flow fractionation and related techniques allow a fine characterization of theses parameters and to better understand the fate of these nanoparticles. We develop methods on our platform for different biotherapeutics. We also develop a miniaturized version of it for enhanced performances.

Massive spheroid formation for nanomedicine drug screening on a chip

The emergence of new immuno-oncotherapies has extended the therapeutic possibilities of many cancers. However, this means interacting with the tumour at a higher level of complexity. Conventional 2D in vitro models cannot satisfactorily model the tumour and its interaction with its environment. Our team is developing frugal methods for the formation and massive screening of tumours to study the potential of nanobiotherapies.

Thermoplastic microfluidics prototyping and cell biology high content screening platform

Our platform is divided in two sections:

• a prototyping platform allowing to design and fabricate polydimethilsiloxane (PDMS) and soft thermoplastic elastomer (sTPE) chips. The platform is oriented toward out-of-clean room frugal production. We recommend contacting Université Paris Cité clean room facility for more complex work
• a microscopy room for videomicroscopy of cell biology and a macroscope assisted with a pressure controller. All our instrument are fully automated, adapted for high content screening and epifluorescence microscopy with usual wavelengths.

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