Centre de Neurophysique, Physiologie et Pathologie - CNRS UMR 8119
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 20 80

Dr. Damien Le Menuet

INSERM researcher, CR- INSERM
Myelination and Nervous system pathologies

damien.le-menuet@-Code to remove to avoid SPAM-inserm.fr
+33 1 70 64 99 76, room H330

Importance of Glucocorticoid Receptors on Peripheral Myelination

Around 2 to 3% of the population is under glucocorticoid (GC) treatment at a given time worldwide. Although very effective, these drugs may come with severe side effects. GC actions are mediated by two receptors: the Mineralocoticoid and Glucococorticoid Receptors (MR and GR respectively). They are highly-related steroid receptors that both bind glucocorticoid hormones (GC) regulating different subsets of genes. MR is a high affinity receptor binding also aldosterone in tight epithelia, while GR is a lower affinity receptor. GC are key modulators of immunity, neurogenesis, memory, mood, stress, metabolism and circadian rhythms. To date, there is surprisingly little data on the role of MR and GR in the peripheral nervous system and more specifically on peripheral myelination, which is provided by Schwann cells (SC). To tackle this issue, we developed mouse models of MR and/or GR knockout in SC that present alteration of locomotor behavior. We use also use SC-derived cell lines and primary SC cultures to better understand glucocorticoid signaling pathways in peripheral myelination.

Recent Publications

Editorial: Steroid receptors in neuron and glia. Le Menuet D, Charalampopoulos IN, Cunningham RL, Kalafatakis K, Nalvarte I. Front Endocrinol (Lausanne). 2024 Aug 14;15:1472908.

Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness. González-Mayoral A, Eid A, Derounian R, Campanella VS, da Silva Ramos A, El Khoury R, Massaad C, Le Menuet D. J Endocrinol. 2023 Jul 12;258(2):e220334.

Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium. Canonica J, Zhao M, Favez T, Gelizé E, Jonet L, Kowalczuk L, Guegan J, Le Menuet D, Viengchareun S, Lombès M, Pussard E, Arsenijevic Y, Behar-Cohen F. Int J Mol Sci. 2021 Sep 5;22(17):9618

Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression. Chen H, Amazit L, Lombès M, Le Menuet D. Neuroscience. 2019 Feb 10;399:12-27.

UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects. Kuhn E, Lamribet K, Viengchareun S, Le Menuet D, Fève B, Lombès M. Ann Endocrinol (Paris). 2019 Feb;80(1):1-9.

Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells. Chen H, Lombès M, Le Menuet D. Mol Brain. 2017 Apr 12;10(1):12.

Journal articles

2023

ref_biblio: Alberto González-Mayoral, Axel Eid, Razmig Derounian, Virginia Sofia Campanella, Andreia da Silva Ramos, et al.. Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness. Journal of Endocrinology, 2023, 258 (2), pp.e220334. ⟨10.1530/JOE-22-0334⟩. ⟨inserm-04163081⟩
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2021

ref_biblio: Jérémie Canonica, Min Zhao, Tatiana Favez, Emmanuelle Gelizé, Laurent Jonet, et al.. Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium. International Journal of Molecular Sciences, 2021, 22 (17), pp.9618. ⟨10.3390/ijms22179618⟩. ⟨hal-03353932⟩
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2019

ref_biblio: Hui Chen, Larbi Amazit, Marc Lombès, Damien Le Menuet. Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression. Neuroscience, 2019, 399, pp.12-27. ⟨10.1016/j.neuroscience.2018.12.012⟩. ⟨inserm-02298752⟩
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ref_biblio: Emmanuelle Kuhn, Khadija Lamribet, Say Viengchareun, Damien Le Menuet, Bruno Fève, et al.. UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects. Annales d'Endocrinologie = Annals of Endocrinology, 2019, 80 (1), pp.1-9. ⟨10.1016/j.ando.2018.04.018⟩. ⟨hal-02189371⟩
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2017

ref_biblio: Hui Chen, Marc Lombès, Damien Le Menuet. Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells. Molecular Brain, 2017, 10 (1), pp.12. ⟨10.1186/s13041-017-0295-x⟩. ⟨inserm-02329880⟩
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2014

ref_biblio: Emmanuelle Kuhn, Christine Bourgeois, Vixra Keo, Say Viengchareun, Adeline Muscat, et al.. Paradoxical resistance to high fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor overexpressing mice.. AJP - Endocrinology and Metabolism, 2014, 306 (1), pp.E75-90. ⟨10.1152/ajpendo.00323.2013⟩. ⟨inserm-00911857⟩
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2013

ref_biblio: Laetitia Martinerie, Mathilde Munier, Damien Le Menuet, Geri Meduri, Say Viengchareun, et al.. The mineralocorticoid signaling pathway throughout development: Expression, regulation and pathophysiological implications. Biochimie, 2013, 95 (2), pp.148-157. ⟨10.1016/j.biochi.2012.09.030⟩. ⟨hal-02955448⟩
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2012

ref_biblio: Damien Le Menuet, Mathilde Munier, Giulia Campostrini, Marc Lombès. Mineralocorticoid receptor and embryonic stem cell models: Molecular insights and pathophysiological relevance. Molecular and Cellular Endocrinology, 2012, 350 (2), pp.216-222. ⟨10.1016/j.mce.2011.06.036⟩. ⟨hal-02955447⟩
Accès au bibtex

ref_biblio: Mathilde Munier, Fredéric Law, Géri Meduri, Damien Le Menuet, Marc Lombes. Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons.. Endocrinology, 2012, 153 (3), pp.1330-40. ⟨10.1210/en.2011-1436⟩. ⟨inserm-00654278⟩
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2010

ref_biblio: Damien Le Menuet, Mathilde Munier, Géri Meduri, Say Viengchareun, Marc Lombès. Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.. Cardiovascular Research, 2010, 87 (3), pp.467-75. ⟨10.1093/cvr/cvq087⟩. ⟨inserm-00463814⟩
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ref_biblio: Mathilde Munier, Geri Meduri, Say Viengchareun, Phillipe Leclerc, Damien Le Menuet, et al.. Regulation of mineralocorticoid receptor expression during neuronal differentiation of murine embryonic stem cells.. Endocrinology, 2010, 151 (5), pp.2244-54. ⟨10.1210/en.2009-0753⟩. ⟨inserm-00450814⟩
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2007

ref_biblio: Say Viengchareun, Damien Le Menuet, Laetitia Martinerie, Mathilde Munier, Laurent Pascual-Le Tallec, et al.. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.. Nuclear Receptor Signaling, 2007, 5, pp.e012. ⟨10.1621/nrs.05012⟩. ⟨inserm-00193515⟩
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