Centre de Neurophysique, Physiologie et Pathologie - CNRS UMR 8119
Université Paris Descartes
45 Rue des Saints Pères
75270 Paris Cedex 06
France

Fax : +33 (0) 1 42 86 20 80

Delphine Meffre

Associate professor, MCU Université Paris Cité
Europe department, Myelination and Nervous system pathologies

delphine.meffre@-Code to remove to avoid SPAM-u-paris.fr
+33 1 42 86 22 73, room H344

Dr Delphine Meffre is Associate professor in Cell biology and Neurosciences at the Faculty of Basic and Biomedical Sciences of Université Paris Cité. Her current research is focused on myelination and remyelination processes of the central nervous system. She is a member of the steering committee of the Institute of Neuroscience and Cognition.

Education

BSc & MSc in Neuroscience from Sorbonne Université, PhD in Neurosciences from Université Paris Sud on the neuroprotective role of progesterone upon brain injury; HDR from Université Paris Descartes on protection and repair in the central nervous system.

Research interests

New therapeutic strategies for myelin repair after central nervous system damage,
Demyelination and remyelination processes in diseases (multiple sclerosis) or after brain injury,
toxic- and mechanical-induced injury models developed in vitro (oligodendroglial cells), ex vivo (organotypic cultures) and in vivo.

Teaching

Neurosciences, Cell biology and Developmental biology for L1 to M2 students at Université Paris Cité.

Co-Chair of the international Master’s program in Neuroscience and M1 co-chair
Co-Coordinator of the Neuroscience Graduate School
Co-Chair for 5 UE from Licence 1 to Master 2
Chair of the Université Ouverte program in Neuroscience and Cognitive Science.

Recent Publications

Idhal: delphine-meffre
ORCID: 0000-0002-9204-2245
Profil Google Scholar

Journal articles

2024

ref_biblio: Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehrani. A Disintegrin And Metalloprotease 10 expression within the murine central nervous system. Brain Research, 2024, 1834, pp.148888. ⟨10.1016/j.brainres.2024.148888⟩. ⟨hal-04595759⟩
Accès au texte intégral et bibtex

2021

ref_biblio: Alex Carrete, Aïda Padilla-Ferrer, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehrani. Effect of Etazolate upon Cuprizone-induced Demyelination In Vivo: Behavioral and Myelin Gene Analysis. Neuroscience, 2021, 455, pp.240-250. ⟨10.1016/j.neuroscience.2020.11.027⟩. ⟨hal-04914549⟩
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2020

ref_biblio: Elena Chierto, Giulia Cristinziano, Francesca Sapone, Delphine Meffre, Mehrnaz Jafarian-Tehrani. Effect of Etazolate on ROS Production after tBHP-Induced Oxidative Stress in Oligodendroglial 158N Cell Line. Reactive Oxygen Species, 2020, ⟨10.20455/ros.2020.807⟩. ⟨hal-04914200⟩
Accès au bibtex

2019

ref_biblio: Gemma Llufriu-Dabén, Delphine Meffre, Charbel Massaad, Mehrnaz Jafarian-Tehrani. A novel model of trauma-induced cerebellar injury and myelin loss in mouse organotypic cerebellar slice cultures using live imaging. Journal of Neuroscience Methods, 2019, 311, pp.385-393. ⟨10.1016/j.jneumeth.2018.09.023⟩. ⟨hal-04914348⟩
Accès au bibtex

2018

ref_biblio: Elena Chierto, Anne Simon, Francesca Castoldi, Delphine Meffre, Giulia Cristinziano, et al.. Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes. Molecular Neurobiology, 2018, 56 (6), pp.4231-4248. ⟨10.1007/s12035-018-1372-6⟩. ⟨hal-04914110⟩
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ref_biblio: Gemma Llufriu-Dabén, Alex Carrete, Elena Chierto, Jo Mailleux, Emeline Camand, et al.. Targeting demyelination via α-secretases promoting sAPPα release to enhance remyelination in central nervous system. Neurobiology of Disease, 2018, 109, pp.11-24. ⟨10.1016/j.nbd.2017.09.008⟩. ⟨hal-04914461⟩
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ref_biblio: Ghjuvan Ghjacumu Shackleford, Nirmal Kumar Sampathkumar, Mehdi Hichor, Laure Weill, Delphine Meffre, et al.. The Involvement of Aryl hydrocarbon receptor in myelination and in human nerve sheath tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America, 2018, 115 (6), pp.E1319-E1328. ⟨10.1073/pnas.1715999115⟩. ⟨hal-02110942⟩
Accès au texte intégral et bibtex

2017

ref_biblio: Ghjuvan’ Ghjacumu Shackleford, Julien Grenier, Walid Abi Habib, Charbel Massaad, Delphine Meffre. Liver X Receptors differentially modulate central myelin gene mRNA levels in a region-, age- and isoform-specific manner. Journal of Steroid Biochemistry and Molecular Biology, 2017, 169, pp.61-68. ⟨10.1016/j.jsbmb.2016.02.032⟩. ⟨hal-04914447⟩
Accès au bibtex

2015

ref_biblio: D. Meffre, C. Massaad, J. Grenier. Lithium chloride stimulates PLP and MBP expression in oligodendrocytes via Wnt/β-catenin and Akt/CREB pathways. Neuroscience, 2015, 284, pp.962-971. ⟨10.1016/j.neuroscience.2014.10.064⟩. ⟨hal-04914441⟩
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ref_biblio: Delphine Meffre, Ghjuvan'Ghjacumu Shackleford, Mehdi Hichor, Victor Gorgievski, Eleni T. Tzavara, et al.. Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (24), pp.7587-7592. ⟨10.1073/pnas.1424951112⟩. ⟨hal-01542311⟩
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ref_biblio: Delphine Meffre, Ghjuvan’ghjacumu Shackleford, Mehdi Hichor, Victor Gorgievski, Eleni Tzavara, et al.. Liver X receptors alpha and beta promote myelination and remyelination in the cerebellum. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 (24), pp.7587-7592. ⟨10.1073/pnas.1424951112⟩. ⟨hal-04516570⟩
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ref_biblio: Fausto Ulloa, Alba Gonzàlez-Juncà, Delphine Meffre, Pablo José Barrecheguren, Ramón Martínez-Mármol, et al.. Blockade of the SNARE Protein Syntaxin 1 Inhibits Glioblastoma Tumor Growth. PLoS ONE, 2015, 10 (3), pp.e0119707. ⟨10.1371/journal.pone.0119707⟩. ⟨hal-04914419⟩
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2013

ref_biblio: D. Meffre, F. Labombarda, B. Delespierre, A. Chastre, A.F. de Nicola, et al.. Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury. Neuroscience, 2013, 231, pp.111-124. ⟨10.1016/j.neuroscience.2012.11.039⟩. ⟨hal-04914379⟩
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2012

ref_biblio: Joelle Makoukji, Martin Belle, Delphine Meffre, Ruth Stassart, Julien Grenier, et al.. Lithium enhances remyelination of peripheral nerves. Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (10), pp.3973-3978. ⟨10.1073/pnas.1121367109⟩. ⟨hal-04914360⟩
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2010

ref_biblio: F. Labombarda, D. Meffre, B. Delespierre, S. Krivokapic-Blondiaux, A. Chastre, et al.. Membrane progesterone receptors localization in the mouse spinal cord. Neuroscience, 2010, 166 (1), pp.94-106. ⟨10.1016/j.neuroscience.2009.12.012⟩. ⟨hal-04914343⟩
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2008

ref_biblio: R. Guennoun, Delphine Meffre, F. Labombarda, S.L. Gonzalez, M.C. Gonzalez Deniselle, et al.. The membrane-associated progesterone-binding protein 25-Dx: Expression, cellular localization and up-regulation after brain and spinal cord injuries. Brain Research Reviews, 2008, 57 (2), pp.493-505. ⟨10.1016/j.brainresrev.2007.05.009⟩. ⟨hal-04914608⟩
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2007

ref_biblio: Delphine Meffre, Brigitte Delespierre, Monique Gouézou, Michael Schumacher, Donald Stein, et al.. 3β-Hydroxysteroid dehydrogenase/5-ene-4-ene isomerase mRNA expression in rat brain: Effect of pseudopregnancy and traumatic brain injury. Journal of Steroid Biochemistry and Molecular Biology, 2007, 104 (3-5), pp.293-300. ⟨10.1016/j.jsbmb.2007.03.003⟩. ⟨hal-04914390⟩
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ref_biblio: D. Meffre, A. Pianos, P. Liere, B. Eychenne, A. Cambourg, et al.. Steroid Profiling in Brain and Plasma of Male and Pseudopregnant Female Rats after Traumatic Brain Injury: Analysis by Gas Chromatography/Mass Spectrometry. Endocrinology, 2007, 148 (5), pp.2505-2517. ⟨10.1210/en.2006-1678⟩. ⟨hal-04914383⟩
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2005

ref_biblio: Delphine Meffre, Brigitte Delespierre, Monique Gouézou, Philippe Leclerc, Gavin Vinson, et al.. The membrane‐associated progesterone‐binding protein 25‐Dx is expressed in brain regions involved in water homeostasis and is up‐regulated after traumatic brain injury. Journal of Neurochemistry, 2005, 93 (5), pp.1314-1326. ⟨10.1111/j.1471-4159.2005.03127.x⟩. ⟨hal-04914385⟩
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Dictionary entry

2013

ref_biblio: Delphine Meffre, Julien Grenier, Sophie Bernard, Françoise Courtin, Todor Dudev, et al.. Wnt and lithium: a common destiny in the therapy of nervous system pathologies?. Wnt and lithium: a common destiny in the therapy of nervous system pathologies?, 2013, pp.1123-1148. ⟨10.1007/s00018-013-1378-1⟩. ⟨hal-04914401⟩
Accès au bibtex

ref_biblio: Ghjuvan’ghjacumu Shackleford, Joelle Makoukji, Julien Grenier, Philippe Liere, Delphine Meffre, et al.. Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes. Differential regulation of Wnt/beta-catenin signaling by Liver X Receptors in Schwann cells and oligodendrocytes, 2013, pp.106-114. ⟨10.1016/j.bcp.2013.02.036⟩. ⟨hal-04914456⟩
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