Sylvie Bortoli

Journal articles

2026

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Russell Cattley, Anneclaire de Roos, Daniele Mandrioli, Neil Pearce, Anjoeka Pronk, et al.. Carcinogenicity of atrazine, alachlor, and vinclozolin. Lancet Oncology, 2026, 27 (1), pp.11-12. ⟨10.1016/S1470-2045(25)00702-8⟩. ⟨hal-05461597⟩

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Lucas Gaillard, Léo Sportes-Milot, Kloé Debizet, Arnaud Tête, Bruno Saubamea, et al.. Repeated exposure to polyethylene microplastic mixtures containing PFAS and bisphenols activates THP-1 macrophages with inflammatory features. Environmental Pollution, 2026, 397, pp.127906. ⟨10.1016/j.envpol.2026.127906⟩. ⟨hal-05752155⟩

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Arnaud Tête, Liana Arnaud, Hélène Le Mentec, Nathalie Poupin, Isabelle Gallais, et al.. Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interactions between genes and environment. Food and Chemical Toxicology, 2026, 215, pp.116228. ⟨10.1016/j.fct.2026.116228⟩. ⟨hal-05675333⟩

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2025

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Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Clémence Rives, Jules Imler, et al.. Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells. Environment International, 2025, 199, pp.109503. ⟨10.1016/j.envint.2025.109503⟩. ⟨hal-05752205⟩

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Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Clémence Rives, Jules Imler, et al.. Triggering tumorigenic signaling: Succinate dehydrogenase inhibitor (SDHi) fungicides induce oncometabolite accumulation and metabolic shift in human colon cells. Environment International, 2025, 199, pp.109503. ⟨10.1016/j.envint.2025.109503⟩. ⟨hal-05098483⟩

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2024

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Chedi Erradhouani, Sylvie Bortoli, Selim Aït-Aïssa, Xavier Coumoul, François Brion. Metabolic disrupting chemicals in the intestine: the need for biologically relevant models. FEBS Open Bio, 2024, 14 (9), pp.1397-1419. ⟨10.1002/2211-5463.13878⟩. ⟨hal-05752210⟩

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2023

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Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, et al.. New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project. Frontiers in Toxicology, 2023, 5, ⟨10.3389/ftox.2023.1220998⟩. ⟨hal-05752217⟩

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Marc Audebert, Ann-Sophie Assmann, Amaya Azqueta, Pavel Babica, Emilio Benfenati, et al.. New approach methodologies to facilitate and improve the hazard assessment of non-genotoxic carcinogens—a PARC project. Frontiers in Toxicology, 2023, 5, ⟨10.3389/ftox.2023.1220998⟩. ⟨hal-05756022⟩

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Arthur Bassot, Béatrice Morio, Sylvie Bortoli, Xavier Coumoul. Le B-A-BA de la mitochondrie, une cheffe d’orchestre intracellulaire très dynamique. Cahiers de Nutrition et de Diététique, 2023, 58 (2), pp.142-154. ⟨10.1016/j.cnd.2022.12.003⟩. ⟨hal-05752219⟩

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Louise Benoit, Celine Tomkiewicz, Maxime Delit, Hanna Khider, Karine Audouze, et al.. Cigarette smoke and tumor microenvironment copromote aggressiveness of human breast cancer cells. Toxicological Sciences, 2023, 192 (1), pp.30-42. ⟨10.1093/toxsci/kfad013⟩. ⟨hal-05752221⟩

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Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Jules Imler, Céline Tomkiewicz-Raulet, et al.. SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex. Environment International, 2023, 180, pp.108219. ⟨10.1016/j.envint.2023.108219⟩. ⟨hal-04748812⟩

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Carolina Duarte Hospital, Arnaud Tête, Kloé Debizet, Jules Imler, Céline Tomkiewicz-Raulet, et al.. SDHi fungicides: An example of mitotoxic pesticides targeting the succinate dehydrogenase complex. Environment International, 2023, 180, pp.108219. ⟨10.1016/j.envint.2023.108219⟩. ⟨hal-04627140⟩

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2022

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Arnaud Tete, Elias Zgheib, Sana Al Awabdh, Louise Benoit, Kévin Bernal, et al.. Alternatives in vitro et in silico aux modèles animaux en toxicologie. Nanotechnologies et biotechnologies pour la santé, 2022, ⟨10.51257/a-v1-re295⟩. ⟨hal-05752223⟩

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2021

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Carolina Duarte-Hospital, Arnaud Tête, François Brial, Louise Benoit, Meriem Koual, et al.. Mitochondrial Dysfunction as a Hallmark of Environmental Injury. Cells, 2021, 11 (1), pp.110. ⟨10.3390/cells11010110⟩. ⟨hal-05756002⟩

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Elias Zgheib, Min Ji Kim, Florence Jornod, Kévin Bernal, Céline Tomkiewicz, et al.. Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration. Environment International, 2021, 154, pp.106574. ⟨10.1016/j.envint.2021.106574⟩. ⟨hal-05755977⟩

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2019

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Paule Bénit, Agathe Kahn, Dominique Chretien, Sylvie Bortoli, Laurence Huc, et al.. Evolutionarily conserved susceptibility of the mitochondrial respiratory chain to SDHI pesticides and its consequence on the impact of SDHIs on human cultured cells. PLoS ONE, 2019, 14 (11), pp.e0224132. ⟨10.1371/journal.pone.0224132⟩. ⟨hal-05755982⟩

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Alix Leblanc, Eléonore Attignon, Emilie Distel, Spyros Karakitsios, Dimosthenis Sarigiannis, et al.. A dual mixture of persistent organic pollutants modifies carbohydrate metabolism in the human hepatic cell line HepaRG. Environmental Research, 2019, 178, pp.108628. ⟨10.1016/j.envres.2019.108628⟩. ⟨hal-05756001⟩

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2018

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Sylvie Bortoli, Martine Collinet, Bernard Desbuquois. Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5′flanking region. Biochimie Open, 2018, 7, pp.26-32. ⟨10.1016/j.biopen.2018.09.001⟩. ⟨hal-05756004⟩

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Sylvie Bortoli, Elisa Boutet-Robinet, Dominique Lagadic-Gossmann, Laurence Huc. Nrf2 and AhR in metabolic reprogramming after contaminant exposure. Current Opinion in Toxicology, 2018, 8, pp.34-41. ⟨10.1016/j.cotox.2017.12.001⟩. ⟨hal-05755983⟩

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2017

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Paule Bénit, Alice Pelhaître, Elise Saunier, Sylvie Bortoli, Assetou Coulibaly, et al.. Paradoxical Inhibition of Glycolysis by Pioglitazone Opposes the Mitochondriopathy Caused by AIF Deficiency. EBioMedicine, 2017, 17, pp.75-87. ⟨10.1016/j.ebiom.2017.02.013⟩. ⟨hal-05755995⟩

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Emilie Distel, Thomas Cadoudal, Martine Collinet, Edwards Park, Chantal Benelli, et al.. Early induction of pyruvate dehydrogenase kinase 4 by retinoic acids in adipocytes. Molecular Nutrition and Food Research, 2017, 61 (5), ⟨10.1002/mnfr.201600920⟩. ⟨hal-05755993⟩

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Ana Fernández-Ramos, Catherine Marchetti-Laurent, Virginie Poindessous, Samantha Antonio, Pierre Laurent-Puig, et al.. 6-mercaptopurine promotes energetic failure in proliferating T cells. Oncotarget, 2017, 8 (26), pp.43048-43060. ⟨10.18632/oncotarget.17889⟩. ⟨hal-05755999⟩

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Ana Fernández-Ramos, Catherine Marchetti-Laurent, Virginie Poindessous, Samantha Antonio, Céline Petitgas, et al.. A comprehensive characterization of the impact of mycophenolic acid on the metabolism of Jurkat T cells. Scientific Reports, 2017, 7 (1), pp.10550. ⟨10.1038/s41598-017-10338-6⟩. ⟨hal-05756000⟩

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Kévin Hardonnière, Morgane Fernier, Isabelle Gallais, Baharia Mograbi, Normand Podechard, et al.. Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype. Scientific Reports, 2017, 7 (1), pp.195. ⟨10.1038/s41598-017-00269-7⟩. ⟨hal-05755996⟩

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Elise Saunier, Samantha Antonio, Anne Regazzetti, Nicolas Auzeil, Olivier Laprévote, et al.. Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells. Scientific Reports, 2017, 7 (1), pp.6945. ⟨10.1038/s41598-017-07006-0⟩. ⟨hal-05755986⟩

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2016

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Kévin Hardonnière, Elise Saunier, Anthony Lemarié, Morgane Fernier, Isabelle Gallais, et al.. The environmental carcinogen benzo[a]pyrene induces a Warburg-like metabolic reprogramming dependent on NHE1 and associated with cell survival. Scientific Reports, 2016, 6 (1), pp.30776. ⟨10.1038/srep30776⟩. ⟨hal-05755987⟩

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2015

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Elise Saunier, Chantal Benelli, Sylvie Bortoli. The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents. International Journal of Cancer, 2015, 138 (4), pp.809-817. ⟨10.1002/ijc.29564⟩. ⟨hal-05755992⟩

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2010

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Jean‐marc Blouin, Graziella Penot, Martine Collinet, Magali Nacfer, Claude Forest, et al.. Butyrate elicits a metabolic switch in human colon cancer cells by targeting the pyruvate dehydrogenase complex. International Journal of Cancer, 2010, 128 (11), pp.2591-2601. ⟨10.1002/ijc.25599⟩. ⟨hal-05755991⟩

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Jean-Marc Blouin, Sylvie Bortoli, Magali Nacfer, Martine Collinet, Graziella Penot, et al.. Down-regulation of the phosphoenolpyruvate carboxykinase gene in human colon tumors and induction by omega-3 fatty acids. Biochimie, 2010, 92 (12), pp.1772-1777. ⟨10.1016/j.biochi.2010.07.011⟩. ⟨hal-05756003⟩

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2008

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Thomas Cadoudal, Emilie Distel, Sylvie Durant, Françoise Fouque, Jean-Marc Blouin, et al.. Pyruvate Dehydrogenase Kinase 4. Diabetes, 2008, 57 (9), pp.2272-2279. ⟨10.2337/db08-0477⟩. ⟨hal-05755989⟩

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2006

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Christelle Rochon, Vincent Frouin, Sylvie Bortoli, Karine Giraud-Triboult, Valérie Duverger, et al.. Comparison of gene expression pattern in SP cell populations from four tissues to define common “stemness functions”. Experimental Cell Research, 2006, 312 (11), pp.2074-2082. ⟨10.1016/j.yexcr.2006.03.010⟩. ⟨hal-05756012⟩

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2005

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Sylvie Bortoli, Valérie Renault, Régine Mariage-Samson, Eric Eveno, Charles Auffray, et al.. Modifications in the myogenic program induced by in vivo and in vitro aging. Gene, 2005, 347 (1), pp.65-72. ⟨10.1016/j.gene.2004.12.029⟩. ⟨hal-05756011⟩

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Charles Decraene, Rachid Benchaouir, Marie-Agnes Dillies, David Israeli, Sylvie Bortoli, et al.. Global transcriptional characterization of SP and MP cells from the myogenic C2C12 cell line: effect of FGF6. Physiological Genomics, 2005, 23 (2), pp.132-149. ⟨10.1152/physiolgenomics.00141.2004⟩. ⟨hal-05756008⟩

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2003

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Sylvie Bortoli, Valérie Renault, Eric Eveno, Charles Auffray, Gill Butler-Browne, et al.. Gene expression profiling of human satellite cells during muscular aging using cDNA arrays. Gene, 2003, 321, pp.145-154. ⟨10.1016/j.gene.2003.08.025⟩. ⟨hal-05756010⟩

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1999

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M Amessou, Sylvie Bortoli, V Liemans, M Collinet, B Desbuquois, et al.. Treatment of streptozotocin-induced diabetic rats with vanadate and phlorizin prevents the over-expression of the liver insulin receptor gene. European Journal of Endocrinology, 1999, pp.79-86. ⟨10.1530/eje.0.1400079⟩. ⟨hal-05756007⟩

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1997

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Sylvie Bortoli, Mohamed Amessou, Martine Collinet, Bernard Desbuquois, Soledad Lopez. Vanadate, But Not Insulin, Inhibits Insulin Receptor Gene Expression in Rat Hepatoma Cells 1. Endocrinology, 1997, 138 (11), pp.4821-4829. ⟨10.1210/endo.138.11.5521⟩. ⟨hal-05756005⟩

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Poster communications

2024

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Arnaud Tête, L. Arnaud, H. Le Mentec, N. Poupin, I. Gallais, et al.. P13-31 Characterization of human isogenic epithelial cell lines as a relevant tool to study colon carcinogenesis and interaction between genes and environment. 58th Congress of the European Societies of Toxicology (EUROTOX 2024), Sep 2024, Copenhague, Denmark. 399, pp.S222-S223, 2024, ⟨10.1016/j.toxlet.2024.07.547⟩. ⟨hal-04690388⟩

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