Team 2 – SysTox

Journal articles

2025

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Jean Guillon, Solène Savrimoutou, Nicolas da Rocha, Sandra Albenque-Rubio, Olivier Helynck, et al.. Design, synthesis, biophysical and biological evaluation of original condensed pyrrolopyrimidine and pyrrolopyridine ligands as anti-SARS-CoV-2 agents targeting G4. European Journal of Medicinal Chemistry, 2025, 292, pp.117655. ⟨10.1016/j.ejmech.2025.117655⟩. ⟨hal-05064440⟩

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2024

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Nour Ayoub, Amit Upadhyay, Arnaud Tête, Nicolas Pietrancosta, Hélène Munier-Lehmann, et al.. Synthesis, evaluation and mechanistic insights of novel IMPDH inhibitors targeting ESKAPEE bacteria. European Journal of Medicinal Chemistry, 2024, 280, pp.116920. ⟨10.1016/j.ejmech.2024.116920⟩. ⟨hal-04749801⟩

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Nour Ayoub, Antoine Gedeon, Hélène Munier-Lehmann. A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis. Frontiers in Pharmacology, 2024, 15, pp.1329011. ⟨10.3389/fphar.2024.1329011⟩. ⟨pasteur-04520637⟩

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Marielle Cochet, François Piumi, Kamila Gorna, Noémie Berry, Gaëlle Gonzalez, et al.. An equine iPSC-based phenotypic screening platform identifies pro- and anti-viral molecules against West Nile virus. Veterinary Research, 2024, 55 (1), pp.32. ⟨10.1186/s13567-024-01290-1⟩. ⟨hal-04568823v2⟩

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Thomas Jaylet, Thibaut Coustillet, Nicola M Smith, Barbara Viviani, Birgitte Lindeman, et al.. Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps. Frontiers in Toxicology, 2024, 6, pp.285768. ⟨10.3389/ftox.2024.1285768⟩. ⟨hal-04668584⟩

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Thomas Jaylet, Thibaut Coustillet, Nicola M Smith, Barbara Viviani, Birgitte Lindeman, et al.. Comprehensive mapping of the AOP-Wiki database: identifying biological and disease gaps. Frontiers in Toxicology, 2024, 6, pp.285768. ⟨10.3389/ftox.2024.1285768⟩. ⟨hal-04765496⟩

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2023

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Mila Collados Rodríguez, Patrick Maillard, Alexandra Journeaux, Anastassia Komarova, Valérie Najburg, et al.. Novel Antiviral Molecules against Ebola Virus Infection. International Journal of Molecular Sciences, 2023, 24 (19), pp.14791. ⟨10.3390/ijms241914791⟩. ⟨hal-04628707⟩

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Thibault Crouzet, Elise Grignard, François Brion, Etienne B Blanc, Normand Podechard, et al.. ReadEDTest: A tool to assess the readiness of in vitro test methods under development for identifying endocrine disruptors. Environment International, 2023, 174, pp.107910. ⟨10.1016/j.envint.2023.107910⟩. ⟨hal-04094681⟩

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Lorenzo Fabbri, Ronan Garlantezec, Karine Audouze, Mariona Bustamante, Ángel Carracedo, et al.. Childhood exposure to non-persistent endocrine disrupting chemicals and multi-omic profiles: A panel study. Environment International, 2023, 173, ⟨10.1016/j.envint.2023.107856⟩. ⟨hal-04059072⟩

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Antoine Gedeon, Nour Ayoub, Sébastien Brûlé, Bertrand Raynal, Gouzel Karimova, et al.. Insight into the role of the Bateman domain at the molecular and physiological levels through engineered IMPDHs. Protein Science, 2023, 32 (8), pp.e4703. ⟨10.1002/pro.4703⟩. ⟨pasteur-04164361⟩

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Antoine Gedeon, Gouzel Karimova, Nour Ayoub, Julien Dairou, Quentin Giai Gianetto, et al.. Interaction network among de novo purine nucleotide biosynthesis enzymes in Escherichia coli. FEBS Journal, 2023, 290, pp.3165-3184. ⟨10.1111/febs.16746⟩. ⟨pasteur-04092979⟩

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E. Mauro, D. Lapaillerie, C. Tumiotto, C. Charlier, F. Martins, et al.. Modulation of the functional interfaces between retroviral intasomes and the human nucleosome. mBio, 2023, 14 (4), pp.e0108323. ⟨10.1128/mbio.01083-23⟩. ⟨hal-04628665v2⟩

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Elke Rouxel, Nathalie Costet, Christine Monfort, Karine Audouze, Lourdes Cirugeda, et al.. Prenatal exposure to multiple persistent organic pollutants in association with adiposity markers and blood pressure in preadolescents. Environment International, 2023, 178, pp.108056. ⟨10.1016/j.envint.2023.108056⟩. ⟨hal-04165701⟩

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Zhicheng Zhou, Isabelle Staropoli, Anne Brelot, Peggy Suzanne, Aurélien Lesnard, et al.. Discovery of Bis-Imidazoline Derivatives as New CXCR4 Ligands. Molecules, 2023, 28 (3), pp.1156. ⟨10.3390/molecules28031156⟩. ⟨pasteur-04096396⟩

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2022

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Florence Jornod, Marylène Rugard, Luc Tamisier, Xavier Coumoul, Helle R Andersen, et al.. AOP4EUpest: mapping of pesticides in adverse outcome pathways using a text mining tool. Bioinformatics, 2022, 36 (15), pp.4379 - 4381. ⟨10.1093/bioinformatics/btaa545⟩. ⟨hal-03741270⟩

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Flora Magnotti, Daria Chirita, Sarah Dalmon, Amandine Martin, Pauline Bronnec, et al.. Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism. Cell Reports, 2022, 41 (2), pp.111472. ⟨10.1016/j.celrep.2022.111472⟩. ⟨hal-03811426⟩

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Patrick Walter, Ariel E Mechaly, Julien Bous, Ahmed Haouz, Patrick England, et al.. Structural basis for the allosteric inhibition of UMP kinase from Gram‐positive bacteria, a promising antibacterial target. FEBS Journal, 2022, 289 (16), pp.4869-4887. ⟨10.1111/febs.16393⟩. ⟨pasteur-04096367⟩

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2021

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Robert Barouki, Karine Audouze, Xavier Coumoul. Perturbateurs endocriniens : de quoi parle-t-on, et quels nouveaux mécanismes de toxicité mettent-ils en jeu ?. La Revue du Praticien Médecine Générale, 2021, 71 (7), pp.723-726. ⟨hal-03744691⟩

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Marc Lavigne, Olivier Helynck, Pascal Rigolet, Rofia Boudria-Souilah, Mireille Nowakowski, et al.. SARS-CoV-2 Nsp3 unique domain SUD interacts with guanine quadruplexes and G4-ligands inhibit this interaction. Nucleic Acids Research, 2021, 49 (13), pp.7695-7712. ⟨10.1093/nar/gkab571⟩. ⟨hal-03281130⟩

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Marylène Rugard, Thomas Jaylet, Olivier Taboureau, Anne Tromelin, Karine Audouze. Smell compounds classification using UMAP to increase knowledge of odors and molecular structures linkages. PLoS ONE, 2021, 16 (5), pp.e0252486. ⟨10.1371/journal.pone.0252486⟩. ⟨hal-03266298⟩

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Qier Wu, Xavier Coumoul, Philippe Grandjean, Robert Barouki, Karine Audouze. Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. Environment International, 2021, 157, pp.106232. ⟨10.1016/j.envint.2020.106232⟩. ⟨hal-03744718⟩

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Elias Zgheib, Min Ji Kim, Florence Jornod, Kévin Bernal, Céline Tomkiewicz, et al.. Identification of non-validated endocrine disrupting chemical characterization methods by screening of the literature using artificial intelligence and by database exploration. Environment International, 2021, 154, pp.106574. ⟨10.1016/j.envint.2021.106574⟩. ⟨hal-03744682⟩

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2020

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João Crispim Encarnação, Valeria Napolitano, Giulia Opassi, U. Helena Danielson, Grzegorz Dubin, et al.. A real‐time cell‐binding assay reveals dynamic features of STxB–Gb3 cointernalization and STxB‐mediated cargo delivery into cancer cells. FEBS Letters, 2020, 594 (15), pp.2406-2420. ⟨10.1002/1873-3468.13847⟩. ⟨pasteur-02892876⟩

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Yanlin Jian, Fabian Hulpia, Martijn D.P. Risseeuw, He Eun Forbes, Hélène Munier-Lehmann, et al.. Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents. European Journal of Medicinal Chemistry, 2020, 201, pp.112450. ⟨10.1016/j.ejmech.2020.112450⟩. ⟨pasteur-02892861⟩

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Yanlin Jian, Romain Merceron, Steven de Munck, He Eun Forbes, Fabian Hulpia, et al.. Endeavors towards transformation of M. tuberculosis thymidylate kinase (MtbTMPK) inhibitors into potential antimycobacterial agents. European Journal of Medicinal Chemistry, 2020, 206, pp.112659. ⟨10.1016/j.ejmech.2020.112659⟩. ⟨pasteur-02998752⟩

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Côme Thieulent, Erika Hue, Gabrielle Sutton, Christine Fortier, Patrick Dallemagne, et al.. Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination. Antiviral Research, 2020, 183, pp.104931. ⟨10.1016/j.antiviral.2020.104931⟩. ⟨hal-03219248⟩

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Côme Thieulent, Christine Fortier, Hélène Munier-Lehmann, Peggy Suzanne, Patrick Dallemagne, et al.. Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: dataset of 2,891 compounds. Data in Brief, 2020, 33, pp.106492. ⟨10.1016/j.dib.2020.106492⟩. ⟨hal-03022297⟩

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José-Carlos Valle-Casuso, Delphine Gaudaire, Lydie Martin-Faivre, Anthony Madeline, Patrick Dallemagne, et al.. Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors. Scientific Reports, 2020, 10 (1), pp.10100. ⟨10.1038/s41598-020-66944-4⟩. ⟨inserm-02888514⟩

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2019

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Thomas Alexandre, Alexandru Lupan, Olivier Helynck, Sophie Vichier-Guerre, Laurence Dugué, et al.. First-in-class allosteric inhibitors of bacterial IMPDHs. European Journal of Medicinal Chemistry, 2019, 167, pp.124-132. ⟨10.1016/j.ejmech.2019.01.064⟩. ⟨pasteur-02125232⟩

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Côme Thieulent, Erika Hue, Christine Fortier, Patrick Dallemagne, Stéphan Zientara, et al.. Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay. Virology, 2019, 526, pp.105-116. ⟨10.1016/j.virol.2018.10.013⟩. ⟨hal-01968305⟩

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2018

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Emna Harigua-Souiai, Yosser Zina Abdelkrim, Imen Bassoumi-Jamoussi, Ons Zakraoui, Guillaume Bouvier, et al.. Identification of novel leishmanicidal molecules by virtual and biochemical screenings targeting Leishmania eukaryotic translation initiation factor 4A. PLoS Neglected Tropical Diseases, 2018, 12 (1), pp.e0006160. ⟨10.1371/journal.pntd.0006160⟩. ⟨pasteur-01968424⟩

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Paris Laskaris, Rocío Vicentefranqueira, Olivier Helynck, Grégory Jouvion, José Antonio Calera, et al.. A Novel Polyaminocarboxylate Compound To Treat Murine Pulmonary Aspergillosis by Interfering with Zinc Metabolism. Antimicrobial Agents and Chemotherapy, 2018, 62 (6), pp.e02510-17. ⟨10.1128/AAC.02510-17⟩. ⟨pasteur-01968421⟩

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Lijun Song, Romain Merceron, Begoña Gracia, Ainhoa Lucía Quintana, Martijn Risseeuw, et al.. Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors. Journal of Medicinal Chemistry, 2018, 61 (7), pp.2753-2775. ⟨10.1021/acs.jmedchem.7b01570⟩. ⟨pasteur-01968413⟩

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Kajitha Suthagar, Wanting Jiao, Hélène Munier-Lehmann, Antony Fairbanks. Synthesis of sulfamide analogues of deoxthymidine monophosphate as potential inhibitors of mycobacterial cell wall biosynthesis. Carbohydrate Research, 2018, 457, pp.32-40. ⟨10.1016/j.carres.2018.01.001⟩. ⟨pasteur-01968406⟩

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2017

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Maria Buchieri, Mena Cimino, Sonia Rebollo-Ramirez, Claire Beauvineau, Alessandro Cascioferro, et al.. Nitazoxanide Analogs Require Nitroreduction for Antimicrobial Activity in Mycobacterium smegmatis. Journal of Medicinal Chemistry, 2017, 60 (17), pp.7425 - 7433. ⟨10.1021/acs.jmedchem.7b00726⟩. ⟨pasteur-01693404⟩

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Stéphanie Dabo, Patrick Maillard, Milagros Collados Rodriguez, Marianne Doré Hansen, Sabrina Mazouz, et al.. Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT. Scientific Reports, 2017, 7 (1), pp.16129. ⟨10.1038/s41598-017-16089-8⟩. ⟨pasteur-01682150⟩

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Samira Khiar, Marianne Lucas-Hourani, Sebastien Nisole, Nikaia Smith, Olivier Helynck, et al.. Identification of a small molecule that primes the type I interferon response to cytosolic DNA. Scientific Reports, 2017, 7 (1), pp.2561. ⟨10.1038/s41598-017-02776-z⟩. ⟨pasteur-01570224⟩

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Marianne Lucas-Hourani, Daniel Dauzonne, Hélène Munier-Lehmann, Samira Khiar, Sébastien Nisole, et al.. Original Chemical Series of Pyrimidine Biosynthesis Inhibitors That Boost the Antiviral Interferon Response. Antimicrobial Agents and Chemotherapy, 2017, 61 (10), pp.e00383-17. ⟨10.1128/AAC.00383-17⟩. ⟨pasteur-01693518⟩

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2016

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Anna Adamska, Anna Rumijowska-Galewicz, Anna Ruszczynska, Mirosława Studzińska, Agnieszka Jabłońska, et al.. Anti-mycobacterial activity of thymine derivatives bearing boron clusters. European Journal of Medicinal Chemistry, 2016, 121, pp.71 - 81. ⟨10.1016/j.ejmech.2016.05.030⟩. ⟨pasteur-01616044⟩

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Clément Grandin, Marianne-Lucas Hourani, Yves L Janin, Daniel Dauzonne, Hélène Munier-Lehmann, et al.. Respiratory syncytial virus infection in macaques is not suppressed by intranasal sprays of pyrimidine biosynthesis inhibitors.. Antiviral Research, 2016, 125, pp.58-62. ⟨10.1016/j.antiviral.2015.11.006⟩. ⟨pasteur-01273178⟩

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Paris Laskaris, Ahmad Atrouni, José Antonio Calera, Christophe d'Enfert, Hélène Munier-Lehmann, et al.. Administration of Zinc Chelators Improves Survival of Mice Infected with Aspergillus fumigatus both in Monotherapy and in Combination with Caspofungin.. Antimicrobial Agents and Chemotherapy, 2016, 60 (10), pp.5631-9. ⟨10.1128/AAC.00324-16⟩. ⟨pasteur-01515325⟩

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Stéphanie Petrella, Alexandra Aubry, Geneviève Janvier, Eloi P. Coutant, Alex Cartier, et al.. Synthesis and evaluation of original bioisosteres of bacterial type IIA topoisomerases inhibitors. Canadian Journal of Chemistry, 2016, 94 (3), pp.240-250. ⟨10.1139/cjc-2015-0475⟩. ⟨pasteur-01386561⟩

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Shriya S Raj, Karthik Krishnan, David S Askew, Olivier S Helynck, Peggy Suzanne, et al.. The Toxicity of a Novel Antifungal Compound Is Modulated by Endoplasmic Reticulum-Associated Protein Degradation (ERAD) Components. Antimicrobial Agents and Chemotherapy, 2016, 60 (3), pp.1438-1449. ⟨10.1128/AAC.02239-15⟩. ⟨pasteur-01427574⟩

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Lijun Song, Martijn D.P. Risseeuw, Matheus Froeyen, Izet Karalic, Jan Goeman, et al.. Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents. Bioorganic and Medicinal Chemistry, 2016, 24 (21), pp.5172 - 5182. ⟨10.1016/j.bmc.2016.08.041⟩. ⟨pasteur-01616045⟩

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2015

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Thomas Alexandre, Bertrand Raynal, Hélène Munier-Lehmann. Two Classes of Bacterial IMPDHs according to Their Quaternary Structures and Catalytic Properties. PLoS ONE, 2015, 10 (2), pp.e0116578. ⟨10.1371/journal.pone.0116578⟩. ⟨pasteur-01174085⟩

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Gilles Labesse, Thomas Alexandre, Muriel Gelin, Ahmed Haouz, Hélène Munier-Lehmann. Crystallographic studies of two variants of Pseudomonas aeruginosa IMPDH with impaired allosteric regulation. Acta crystallographica Section D : Structural biology [1993-..], 2015, 71, pp.1890-1899. ⟨10.1107/S1399004715013115⟩. ⟨pasteur-01197071⟩

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Marianne Lucas-Hourani, Hélène Munier-Lehmann, Farah El Mazouni, Nicholas A Malmquist, Jane Harpon, et al.. Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH).. Journal of Medicinal Chemistry, 2015, 58 (14), pp.5579 - 5598. ⟨10.1021/acs.jmedchem.5b00606⟩. ⟨pasteur-01170546⟩

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Hélène Munier-Lehmann, Marianne Lucas-Hourani, Sandrine Guillou, Olivier Helynck, Gigliola Zanghi, et al.. Original 2-(3-Alkoxy-1H-pyrazol-1-yl)pyrimidine Derivatives as Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH). Journal of Medicinal Chemistry, 2015, 58, pp.860-877. ⟨10.1021/jm501446r⟩. ⟨pasteur-01101526⟩

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Pierre-Olivier Vidalain, Marianne Lucas-Hourani, Olivier Helynck, Frédéric Tangy, Hélène Munier-Lehmann. Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening. Médecine/Sciences, 2015, 31 (1), pp.98-104. ⟨10.1051/medsci/20153101019⟩. ⟨pasteur-01174082⟩

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2014

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Marianne Lucas-Hourani, Hélène Munier-Lehmann, Olivier Helynck, Anastassia Komarova, Philippe Desprès, et al.. High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses. Journal of visualized experiments : JoVE, 2014, 87, pp.e51222. ⟨10.3791/51222⟩. ⟨pasteur-01113538⟩

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2013

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Nathalie Aulner, Anne Danckaert, Eline Rouault-Hardoin, Julie Desrivot, Olivier Helynck, et al.. High content analysis of primary macrophages hosting proliferating Leishmania amastigotes: application to anti-leishmanial drug discovery.. PLoS Neglected Tropical Diseases, 2013, 7 (4), pp.e2154. ⟨10.1371/journal.pntd.0002154⟩. ⟨pasteur-01433415⟩

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Clément Carré, Caroline Jacquier, Anne-Laure Bougé, Fabrice de Chaumont, Corinne Besnard-Guerin, et al.. AutomiG, a biosensor to detect alterations in miRNA biogenesis and in small RNA silencing guided by perfect target complementarity.. PLoS ONE, 2013, 8 (9), pp.e74296. ⟨10.1371/journal.pone.0074296⟩. ⟨pasteur-00877254⟩

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Gilles Labesse, Thomas Alexandre, Laurène Vaupré, Isabelle Salard-Arnaud, Joséphine Lai Kee Him, et al.. MgATP regulates allostery and fiber formation in IMPDHs.. Structure, 2013, 21 (6), pp.975-85. ⟨10.1016/j.str.2013.03.011⟩. ⟨pasteur-00849842⟩

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Marianne Lucas-Hourani, Daniel Dauzonne, Pierre Jorda, Gaëlle Cousin, Alexandru Lupan, et al.. Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity. PLoS Pathogens, 2013, 9 (10), pp.e1003678. ⟨10.1371/journal.ppat.1003678⟩. ⟨pasteur-01113535⟩

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Marianne Lucas-Hourani, Alexandru Lupan, Philippe Desprès, Sylviane Thoret, Olivier Pamlard, et al.. A phenotypic assay to identify chikungunya virus inhibitors targeting the nonstructural protein nsP2.. Journal of Biomolecular Screening, 2013, 18 (2), pp.172-9. ⟨10.1177/1087057112460091⟩. ⟨hal-00798263⟩

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Hélène Munier-Lehmann, Pierre-Olivier Vidalain, Frédéric Tangy, Yves Louis Janin. On dihydroorotate dehydrogenases and their inhibitors and uses.. Journal of Medicinal Chemistry, 2013, 56 (8), pp.3148-67. ⟨10.1021/jm301848w⟩. ⟨pasteur-00819070⟩

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Kiran S Toti, Frederick Verbeke, Martijn D P Risseeuw, Vladimir Frecer, Hélène Munier-Lehmann, et al.. Synthesis and evaluation of 5'-modified thymidines and 5-hydroxymethyl-2'-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors.. Bioorganic and Medicinal Chemistry, 2013, 21 (1), pp.257-68. ⟨10.1016/j.bmc.2012.10.018⟩. ⟨pasteur-00849837⟩

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Ute Zeidler, Marie-Elisabeth Bougnoux, Alexandru Lupan, Olivier Helynck, Antonia Doyen, et al.. Synergy of the antibiotic colistin with echinocandin antifungals in Candida species.. Journal of Antimicrobial Chemotherapy, 2013, 68 (6), pp.1285-96. ⟨10.1093/jac/dks538⟩. ⟨pasteur-00849830⟩

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2012

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Cécile Clavaud, Anne Beauvais, Lise Barbin, Hélène Munier-Lehmann, Jean-Paul Latgé. The Composition of the Culture Medium Influences the β-1,3-Glucan Metabolism of Aspergillus fumigatus and the Antifungal Activity of Inhibitors of β-1,3-Glucan Synthesis. Antimicrobial Agents and Chemotherapy, 2012, 56 (6), pp.3428 - 3431. ⟨10.1128/AAC.05661-11⟩. ⟨pasteur-01725799⟩

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Martin Kögler, Roger Busson, Steven de Jonghe, Jef Rozenski, Kristien van Belle, et al.. Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.. Chemistry and Biodiversity, 2012, 9 (3), pp.536-56. ⟨10.1002/cbdv.201100285⟩. ⟨pasteur-00705897⟩

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S. van Calenbergh, Sylvie Pochet, Hélène Munier-Lehmann. Drug design and identification of potent leads against Mycobacterium tuberculosis thymidine monophosphate kinase.. Current Topics in Medicinal Chemistry, 2012, 12 (7), pp.694-705. ⟨10.2174/156802612799984580⟩. ⟨pasteur-00705879⟩

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2011

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Gilles Labesse, Khaled Benkali, Isabelle Salard-Arnaud, Anne-Marie Gilles, Hélène Munier-Lehmann. Structural and functional characterization of the Mycobacterium tuberculosis uridine monophosphate kinase: insights into the allosteric regulation.. Nucleic Acids Research, 2011, 39 (8), pp.3458-72. ⟨10.1093/nar/gkq1250⟩. ⟨pasteur-00589535⟩

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Sara van Poecke, Hélène Munier-Lehmann, Olivier Helynck, Matheus Froeyen, Serge van Calenbergh. Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase.. Bioorganic and Medicinal Chemistry, 2011, 19, epub ahead of print. ⟨10.1016/j.bmc.2011.10.021⟩. ⟨pasteur-00645423⟩

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2010

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Olga Familiar, Hélène Munier-Lehmann, José Antonio Aínsa, María-José Camarasa, María-Jesús Pérez-Pérez. Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.. European Journal of Medicinal Chemistry, 2010, 45 (12), pp.5910-8. ⟨10.1016/j.ejmech.2010.09.056⟩. ⟨pasteur-00589542⟩

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2009

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Constance Auvynet, Dimitri Topalis, Christophe Caillat, Hélène Munier-Lehmann, Edward Seclaman, et al.. Phosphorylation of dGMP analogs by vaccinia virus TMP kinase and human GMP kinase.. Biochemical and Biophysical Research Communications, 2009, 388 (1), pp.6-11. ⟨10.1016/j.bbrc.2009.07.089⟩. ⟨pasteur-00417244⟩

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2008

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Johan Binesse, Claude Delsert, Denis Saulnier, Marie-Christine Champomier-Vergès, Monique Zagorec, et al.. Metalloprotease Vsm Is the Major Determinant of Toxicity for Extracellular Products of Vibrio splendidus. Applied and Environmental Microbiology, 2008, 74 (23), pp.7108-7117. ⟨10.1128/AEM.01261-08⟩. ⟨hal-02922079⟩

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ref_biblio

Olga Familiar, Hélène Munier-Lehmann, Ana Negri, Federico Gago, Dominique Douguet, et al.. Exploring acyclic nucleoside analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.. ChemMedChem, 2008, 3 (7), pp.1083-93. ⟨10.1002/cmdc.200800060⟩. ⟨pasteur-00316018⟩

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Cécile Gasse, Dominique Douguet, Valérie Huteau, Gilles Marchal, Hélène Munier-Lehmann, et al.. Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity.. Bioorganic and Medicinal Chemistry, 2008, 16 (11), pp.6075-85. ⟨10.1016/j.bmc.2008.04.045⟩. ⟨pasteur-00307723⟩

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ref_biblio

D. Topalis, K. Alvarez, K. Barral, Hélène Munier-Lehmann, B. Schneider, et al.. Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.. Nucleosides, Nucleotides and Nucleic Acids, 2008, 27 (4), pp.319-31. ⟨10.1080/15257770801941952⟩. ⟨pasteur-00316017⟩

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2007

ref_biblio

Cécile Gasse, Valérie Huteau, Dominique Douguet, Hélène Munier-Lehmann, Sylvie Pochet. A new family of inhibitors of mycobacterium tuberculosis thymidine monophosphate kinase.. Nucleosides, Nucleotides and Nucleic Acids, 2007, 26 (8-9), pp.1057-61. ⟨10.1080/15257770701513349⟩. ⟨pasteur-00202300⟩

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Augustin Ofiteru, Nadia Bucurenci, Emil Alexov, Thomas Bertrand, Pierre Briozzo, et al.. Structural and functional consequences of single amino acid substitutions in the pyrimidine base binding pocket of Escherichia coli CMP kinase.. FEBS Journal, 2007, 274 (13), pp.3363-73. ⟨10.1111/j.1742-4658.2007.05870.x⟩. ⟨pasteur-00166939⟩

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Ineke van Daele, Hélène Munier-Lehmann, Matheus Froeyen, Jan Balzarini, Serge van Calenbergh. Rational design of 5'-thiourea-substituted alpha-thymidine analogues as thymidine monophosphate kinase inhibitors capable of inhibiting mycobacterial growth.. Journal of Medicinal Chemistry, 2007, 50 (22), pp.5281-92. ⟨10.1021/jm0706158⟩. ⟨hal-01197105⟩

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2006

ref_biblio

Marco Bellinzoni, Ahmed Haouz, Martin Graña, Hélène Munier-Lehmann, William Shepard, et al.. The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.. Protein Science, 2006, 15 (6), pp.1489-93. ⟨10.1110/ps.062163406⟩. ⟨pasteur-00166948⟩

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Emmanuel Frachon, Vincent Bondet, Hélène Munier-Lehmann, Jacques Bellalou. Multiple microfermentor battery: a versatile tool for use with automated parallel cultures of microorganisms producing recombinant proteins and for optimization of cultivation protocols.. Applied and Environmental Microbiology, 2006, 72 (8), pp.5225-31. ⟨10.1128/AEM.00239-06⟩. ⟨pasteur-00166941⟩

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Guillaume Hible, Petya Christova, Louis Renault, Edward Seclaman, Andrew Thompson, et al.. Unique GMP-binding site in Mycobacterium tuberculosis guanosine monophosphate kinase.. Proteins - Structure, Function and Bioinformatics, 2006, 62 (2), pp.489-500. ⟨10.1002/prot.20662⟩. ⟨pasteur-00166951⟩

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Ineke van Daele, Hélène Munier-Lehmann, Pieter M S Hendrickx, Gilles Marchal, Pierre Chavarot, et al.. Synthesis and biological evaluation of bicyclic nucleosides as inhibitors of M. tuberculosis thymidylate kinase.. ChemMedChem, 2006, 1 (10), pp.1081-90. ⟨10.1002/cmdc.200600028⟩. ⟨pasteur-00166946⟩

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2005

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Dominique Douguet, Hélène Munier-Lehmann, Gilles Labesse, Sylvie Pochet. LEA3D: a computer-aided ligand design for structure-based drug design.. Journal of Medicinal Chemistry, 2005, 48 (7), pp.2457-68. ⟨10.1021/jm0492296⟩. ⟨pasteur-00166207⟩

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Emanuela Fioravanti, Virgile Adam, Hélène Munier-Lehmann, Dominique Bourgeois. The crystal structure of Mycobacterium tuberculosis thymidylate kinase in complex with 3'-azidodeoxythymidine monophosphate suggests a mechanism for competitive inhibition.. Biochemistry, 2005, 44 (1), pp.130-7. ⟨10.1021/bi0484163⟩. ⟨pasteur-00166954⟩

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2004

ref_biblio

Jacques Gallay, Michel Vincent, Inès M Li de La Sierra, Hélène Munier-Lehmann, Madalena Renouard, et al.. Insight into the activation mechanism of Bordetella pertussis adenylate cyclase by calmodulin using fluorescence spectroscopy.. European Journal of Biochemistry, 2004, 271 (4), pp.821-33. ⟨10.1111/j.1432-1033.2004.03987.x⟩. ⟨pasteur-00166965⟩

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Ruth Gretchen León, Hélène Munier-Lehmann, Octavian Barzu, Véronique Baudin-Creuza, Ruth Pietri, et al.. High-level production of recombinant sulfide-reactive hemoglobin I from Lucina pectinata in Escherichia coli. High yields of fully functional holoprotein synthesis in the BLi5 E. coli strain.. Protein Expression and Purification, 2004, 38 (2), pp.184-95. ⟨10.1016/j.pep.2004.08.014⟩. ⟨pasteur-00166962⟩

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Simona Miron, Hélène Munier-Lehmann, Constantin T. Craescu. Structural and dynamic studies on ligand-free adenylate kinase from Mycobacterium tuberculosis revealed a closed conformation that can be related to the reduced catalytic activity.. Biochemistry, 2004, 43 (1), pp.67-77. ⟨10.1021/bi0355995⟩. ⟨pasteur-00166963⟩

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Veerle Vanheusden, Hélène Munier-Lehmann, Matheus Froeyen, Roger Busson, Jef Rozenski, et al.. Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.. Journal of Medicinal Chemistry, 2004, 47 (25), pp.6187-94. ⟨10.1021/jm040847w⟩. ⟨pasteur-00166959⟩

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2003

ref_biblio

Emanuela Fioravanti, Ahmed Haouz, Thomas Ursby, Hélène Munier-Lehmann, Marc Delarue, et al.. Mycobacterium tuberculosis thymidylate kinase: structural studies of intermediates along the reaction pathway.. Journal of Molecular Biology, 2003, 327 (5), pp.1077-92. ⟨10.1016/S0022-2836(03)00202-X⟩. ⟨pasteur-00167041⟩

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ref_biblio

Ahmed Haouz, Veerle Vanheusden, Hélène Munier-Lehmann, Mattheus Froeyen, Piet Herdewijn, et al.. Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism.. Journal of Biological Chemistry, 2003, 278 (7), pp.4963-71. ⟨10.1074/jbc.M209630200⟩. ⟨pasteur-00167043⟩

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Hélène Munier-Lehmann, Viviane Chenal-Francisque, Mihaela Ionescu, Petya Chrisova, Jeannine Foulon, et al.. Relationship between bacterial virulence and nucleotide metabolism: a mutation in the adenylate kinase gene renders Yersinia pestis avirulent.. Biochemical Journal, 2003, 373 (Pt 2), pp.515-22. ⟨10.1042/BJ20030284⟩. ⟨pasteur-00167039⟩

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ref_biblio

Hélène Munier-Lehmann, Sylvie Pochet, Laurence Dugué, Olivier Dutruel, Gilles Labesse, et al.. Design of Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors.. Nucleosides, Nucleotides and Nucleic Acids, 2003, 22 (5-8), pp.801-4. ⟨10.1081/NCN-120022638⟩. ⟨pasteur-00166202⟩

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Claudia Pasti, Sarah Gallois-Montbrun, Hélène Munier-Lehmann, Michel Veron, Anne-Marie Gilles, et al.. Reaction of human UMP-CMP kinase with natural and analog substrates.. European Journal of Biochemistry, 2003, 270 (8), pp.1784-90. ⟨10.1046/j.1432-1033.2003.03537.x⟩. ⟨pasteur-00167042⟩

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ref_biblio

Sylvie Pochet, Laurence Dugué, Gilles Labesse, Muriel Delepierre, Hélène Munier-Lehmann. Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans.. ChemBioChem, 2003, 4 (8), pp.742-7. ⟨10.1002/cbic.200300608⟩. ⟨pasteur-00165348⟩

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ref_biblio

Philippe van Rompaey, Koen Nauwelaerts, Veerle Vanheusden, Jef Rozenski, Hélène Munier-Lehmann, et al.. Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2 '- and 3 '-modified thymidine analogues. European Journal of Organic Chemistry, 2003, 15, pp.2911-2918. ⟨10.1002/ejoc.200300177⟩. ⟨pasteur-00167037⟩

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Veerle Vanheusden, Hélène Munier-Lehmann, Matheus Froeyen, Laurence Dugué, Arne Heyerick, et al.. 3'-C-branched-chain-substituted nucleosides and nucleotides as potent inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase.. Journal of Medicinal Chemistry, 2003, 46 (18), pp.3811-21. ⟨10.1021/jm021108n⟩. ⟨pasteur-00166204⟩

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Veerle Vanheusden, Philippe van Rompaey, Hélène Munier-Lehmann, Sylvie Pochet, Piet Herdewijn, et al.. Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.. Bioorganic and Medicinal Chemistry Letters, 2003, 13 (18), pp.3045-8. ⟨10.1016/S0960-894X(03)00643-7⟩. ⟨pasteur-00166206⟩

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2002

ref_biblio

Thomas Bertrand, Pierre Briozzo, Liliane Assairi, Augustin Ofiteru, Nadia Bucurenci, et al.. Sugar specificity of bacterial CMP kinases as revealed by crystal structures and mutagenesis of Escherichia coli enzyme.. Journal of Molecular Biology, 2002, 315 (5), pp.1099-110. ⟨10.1006/jmbi.2001.5286⟩. ⟨pasteur-00167047⟩

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Dominique Douguet, Jean-Michel Bolla, Hélène Munier-Lehmann, G. Labesse. From sequence to structure to function: a case study. Enzyme and Microbial Technology, 2002, 30 (3), pp.289-294. ⟨10.1016/S0141-0229(01)00501-4⟩. ⟨pasteur-00167045⟩

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David T Manallack, Mark R Sanderson, Maninder Sohi, Frank Wien, Helene Munier-Lehmann, et al.. Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods.. Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (3), pp.167-74. ⟨10.1080/14756360290032949⟩. ⟨pasteur-00167044⟩

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ref_biblio

Sylvie Pochet, Laurence Dugué, Dominique Douguet, Gilles Labesse, Hélène Munier-Lehmann. Nucleoside analogues as inhibitors of thymidylate kinases: possible therapeutic applications.. ChemBioChem, 2002, 3 (1), pp.108-10. ⟨10.1002/1439-7633(20020104)3:1<108::AID-CBIC108>3.0.CO;2-B⟩. ⟨pasteur-00166196⟩

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ref_biblio

Veerle Vanheusden, Hélène Munier-Lehmann, Sylvie Pochet, Piet Herdewijn, Serge van Calenbergh. Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase.. Bioorganic and Medicinal Chemistry Letters, 2002, 12 (19), pp.2695-8. ⟨10.1016/S0960-894X(02)00551-6⟩. ⟨pasteur-00166198⟩

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2001

ref_biblio

Inès Li de La Sierra, Hélène Munier-Lehmann, Anne-Marie Gilles, Octavian Bârzu, Marc Delarue. X-ray structure of TMP kinase from Mycobacterium tuberculosis complexed with TMP at 1.95 A resolution.. Journal of Molecular Biology, 2001, 311 (1), pp.87-100. ⟨10.1006/jmbi.2001.4843⟩. ⟨pasteur-00167054⟩

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ref_biblio

Simona Miron, Hélène Munier-Lehmann, Constantin T. Craescu. 1H, 13C and 15N resonance assignment and secondary structure of Mycobacterium tuberculosis adenylate kinase.. Journal of Biomolecular NMR, 2001, 19 (1), pp.89-90. ⟨10.1023/A%3A1008392515781⟩. ⟨pasteur-00167071⟩

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ref_biblio

Hélène Munier-Lehmann, Alain Chaffotte, Sylvie Pochet, Gilles Labesse. Thymidylate kinase of Mycobacterium tuberculosis: a chimera sharing properties common to eukaryotic and bacterial enzymes.. Protein Science, 2001, 10 (6), pp.1195-205. ⟨10.1110/ps.45701⟩. ⟨pasteur-00167069⟩

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2000

ref_biblio

Inès Li de La Sierra, Hélène Munier-Lehmann, Anne-Marie Gilles, Octavian Bârzu, Marc Delarue. Crystallization and preliminary X-ray analysis of the thymidylate kinase from Mycobacterium tuberculosis.. Acta crystallographica Section D : Structural biology [1993-..], 2000, 56 (Pt 2), pp.226-8. ⟨10.1107/S0907444999016212⟩. ⟨pasteur-00167073⟩

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1999

ref_biblio

Hélène Munier-Lehmann, Simona Burlacu-Miron, Constantin T. Craescu, Henry H. Mantsch, C. P. Schultz. A new subfamily of short bacterial adenylate kinases with the Mycobacterium tuberculosis enzyme as a model: A predictive and experimental study.. Proteins - Structure, Function and Bioinformatics, 1999, 36 (2), pp.238-48. ⟨pasteur-00167076⟩

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1996

ref_biblio

Ahmed Bouhss, Michel Vincent, Hélène Munier, Anne-Marie Gilles, Masayuchi Takahashi, et al.. Conformational transitions within the calmodulin-binding site of Bordetella pertussis adenylate cyclase studied by time-resolved fluorescence of Trp242 and circular dichroism.. European Journal of Biochemistry, 1996, 237 (3), pp.619-28. ⟨10.1111/j.1432-1033.1996.0619p.x⟩. ⟨pasteur-00167087⟩

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ref_biblio

Fabienne Mauxion, Roland Le Borgne, Hélène Munier-Lehmann, Bernard Hoflack. A Casein Kinase II Phosphorylation Site in the Cytoplasmic Domain of the Cation-dependent Mannose 6-Phosphate Receptor Determines the High Affinity Interaction of the AP-1 Golgi Assembly Proteins with Membranes. Journal of Biological Physics and Chemistry, 1996, 271 (4), pp.2171-2178. ⟨10.1074/jbc.271.4.2171⟩. ⟨hal-01197131⟩

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ref_biblio

Fabienne Mauxion, Roland Le Borgne, Hélène Munier-Lehmann, Bernard Hoflack. A casein kinase II phosphorylation site in the cytoplasmic domain of the cation-dependent mannose 6-phosphate receptor determines the high affinity interaction of the AP-1 Golgi assembly proteins with membranes.. Journal of Biological Chemistry, 1996, 271 (4), pp.2171-8. ⟨pasteur-00167083⟩

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ref_biblio

Hélène Munier-Lehmann, Fabienne Mauxion, Bernard Hoflack. Function of the two mannose 6-phosphate receptors in lysosomal enzyme transport.. Biochemical Society Transactions, 1996, 24 (1), pp.133-6. ⟨pasteur-00167081⟩

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ref_biblio

Hélène Munier-Lehmann, F. Mauxion, U. Bauer, Peter Lobel, Bernard Hoflack. Re-expression of the mannose 6-phosphate receptors in receptor-deficient fibroblasts. Complementary function of the two mannose 6-phosphate receptors in lysosomal enzyme targeting.. Journal of Biological Chemistry, 1996, 271 (25), pp.15166-74. ⟨pasteur-00167079⟩

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ref_biblio

Hélène Munier-Lehmann, F Mauxion, U Bauer, P Lobel, B Hoflack. Re-expression of the Mannose 6-Phosphate Receptors in Receptor-deficient Fibroblasts. COMPLEMENTARY FUNCTION OF THE TWO MANNOSE 6-PHOSPHATE RECEPTORS IN LYSOSOMAL ENZYME TARGETING. Journal of Biological Physics and Chemistry, 1996, 271 (25), pp.15166-74. ⟨10.1074/jbc.271.25.15166⟩. ⟨hal-01197122⟩

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1995

ref_biblio

Hélène Munier, A. Bouhss, A. M. Gilles, Nicolae Palibroda, O. Bârzu, et al.. Structural characterization by nuclear magnetic resonance spectroscopy of a genetically engineered high-affinity calmodulin-binding peptide derived from Bordetella pertussis adenylate cyclase.. Archives of Biochemistry and Biophysics, 1995, 320 (2), pp.224-35. ⟨10.1016/0003-9861(95)90004-7⟩. ⟨pasteur-00167088⟩

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1994

ref_biblio

Thomas Ludwig, Hélène Munier-Lehmann, Ulrike Bauer, Michael Hollinshead, Catherine Ovitt, et al.. Differential sorting of lysosomal enzymes in mannose 6-phosphate receptor-deficient fibroblasts.. EMBO Journal, 1994, 13 (15), pp.3430-7. ⟨pasteur-00167086⟩

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1993

ref_biblio

Ahmed Bouhss, Evelyne Krin, Hélène Munier, Anne-Marie Gilles, Antoine Danchin, et al.. Cooperative phenomena in binding and activation of Bordetella pertussis adenylate cyclase by calmodulin.. Journal of Biological Chemistry, 1993, 268 (3), pp.1690-4. ⟨pasteur-00167092⟩

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ref_biblio

A. M. Gilles, Odile Sismeiro, Hélène Munier, H. Fabian, H. H. Mantsch, et al.. Structural and physico-chemical characteristics of Bordetella pertussis adenylate kinase, a tryptophan-containing enzyme.. European Journal of Biochemistry, 1993, 218 (3), pp.921-7. ⟨10.1111/j.1432-1033.1993.tb18448.x⟩. ⟨pasteur-00167089⟩

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Hélène Munier, Francisco J. Blanco, Bénédicte Prêcheur, Eric Diesis, José L. Nieto, et al.. Characterization of a synthetic calmodulin-binding peptide derived from Bacillus anthracis adenylate cyclase.. Journal of Biological Chemistry, 1993, 268 (3), pp.1695-701. ⟨pasteur-00167091⟩

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ref_biblio

Hélène Munier, Ahmed Bouhss, A. M. Gilles, Evelyne Krin, Philippe Glaser, et al.. Structural flexibility of the calmodulin-binding locus in Bordetella pertussis adenylate cyclase. Reconstitution of catalytically active species from fragments or inactive forms of the enzyme.. European Journal of Biochemistry, 1993, 217 (2), pp.581-6. ⟨10.1111/j.1432-1033.1993.tb18280.x⟩. ⟨pasteur-00167090⟩

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1992

ref_biblio

Hélène Munier, Ahmed Bouhss, Evelyne Krin, Antoine Danchin, Anne-Marie Gilles, et al.. The role of histidine 63 in the catalytic mechanism of Bordetella pertussis adenylate cyclase.. Journal of Biological Chemistry, 1992, 267 (14), pp.9816-20. ⟨pasteur-00167093⟩

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ref_biblio

B. Prêcheur, Hélène Munier, Joël Mispelter, O. Bârzu, Constantin T. Craescu. 1H and 15N NMR characterization of free and bound states of an amphiphilic peptide interacting with calmodulin.. Biochemistry, 1992, 31 (1), pp.229-36. ⟨pasteur-00167094⟩

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1991

ref_biblio

Philippe Glaser, Hélène Munier, Anne-Marie Gilles, Evelyne Krin, Tudor Porumb, et al.. Functional consequences of single amino acid substitutions in calmodulin-activated adenylate cyclase of Bordetella pertussis.. EMBO Journal, 1991, 10 (7), pp.1683-8. ⟨pasteur-00167099⟩

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ref_biblio

E. Labruyère, M. Mock, W. K. Surewicz, H. H. Mantsch, T. Rose, et al.. Structural and ligand-binding properties of a truncated form of Bacillus anthracis adenylate cyclase and of a catalytically inactive variant in which glutamine substitutes for lysine-346.. Biochemistry, 1991, 30 (10), pp.2619-24. ⟨10.1021/bi00224a008⟩. ⟨pasteur-00167101⟩

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ref_biblio

Hélène Munier, Anne-Marie Gilles, Philippe Glaser, Evelyne Krin, Antoine Danchin, et al.. Isolation and characterization of catalytic and calmodulin-binding domains of Bordetella pertussis adenylate cyclase.. European Journal of Biochemistry, 1991, 196 (2), pp.469-74. ⟨10.1111/j.1432-1033.1991.tb15838.x⟩. ⟨pasteur-00167100⟩

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ref_biblio

Robert S. Sarfati, Abdelkader Namane, Hélène Munier, Octavian Barzu. New fluorescent and photoactivable analogs acting on nucleotide binding enzymes. Tetrahedron Letters, 1991, 32 (36), pp.4699-4702. ⟨10.1016/S0040-4039(00)92285-8⟩. ⟨pasteur-00167097⟩

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1990

ref_biblio

Anne-Marie Gilles, Hélène Munier, Thierry Rose, Philippe Glaser, Evelyne Krin, et al.. Intrinsic fluorescence of a truncated Bordetella pertussis adenylate cyclase expressed in Escherichia coli.. Biochemistry, 1990, 29 (35), pp.8126-30. ⟨pasteur-00167103⟩

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ref_biblio

Robert S. Sarfati, Vinod K. Kansal, Hélène Munier, Philippe Glaser, Anne-Marie Gilles, et al.. Binding of 3'-anthraniloyl-2'-deoxy-ATP to calmodulin-activated adenylate cyclase from Bordetella pertussis and Bacillus anthracis.. Journal of Biological Chemistry, 1990, 265 (31), pp.18902-6. ⟨pasteur-00167102⟩

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Conference papers

2024

ref_biblio

Anne-Lise Pocheron, Mirjana Antonijevic, Gabrielle Bouet, Delphine Froger, Fanny Lecouturier, et al.. Drug library screening for putative antiviral compounds'discovery against equine arteritis virus. 12th International Equine Infectious Diseases Conference, EIDC, Sep 2024, Deauville, France. pp.56-57 (n°83), ⟨10.1111/evj.14298⟩. ⟨hal-04723725⟩

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2022

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Jose Carlos Valle-Casuso, Delphine Gaudaire, Patrick Dallemagne, Stéphane Pronost, Hélène Munier-Lehmann, et al.. La réplication du virus de l'artérite équine est efficacement supprimée par les inhibiteurs de la biosynthèse des purines et des pyrimidines. Journées scientifiques et doctorales de l'Anses (JSDA), Anses, Oct 2022, Maisons-Alfort, France. ⟨anses-04571182⟩

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2021

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Gabrielle Bouet, Delphine Gaudaire, A. Madeline, Patrick Dallemagne, Stéphane Pronost, et al.. Development of a high‐throughput screening assay to identify equine virus arteritis replication inhibitors. 11th International Equine Infectious Diseases Conference, EIDC, Sep 2021, Online, France. pp.63-64, ⟨10.1111/evj.95_13495⟩. ⟨hal-03374819⟩

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Marielle Cochet-Bernoin, François Piumi, Kamila Gorna, Gaelle Gonzalez, Anne Danckaert, et al.. Identification of antiviral molecules against West-Nile virus by an approach combining cell imaging and equine neural cells derived from induced-pluripotent stem cells.. International Equine Infectious Diseases Conference 2021 - IEIDC XI, Sep 2021, DEAUVILLE, France. ⟨hal-03355807⟩

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Côme Thieulent, Erika Hue, Gabrielle Sutton, Christine Fortier, Patrick Dallemagne, et al.. Identification of antiviral compounds against equid herpesvirus‐1 using Real‐Time Cell Analysis: screening of 2,891 molecules. 11th International Equine Infectious Diseases Conference, Sep 2021, Online, France. ⟨10.1111/evj.83_13495⟩. ⟨hal-03405801⟩

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2020

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Côme Thieulent, Erika Hue, Christine Fortier, Patrick Dallemagne, Stéphan Zientara, et al.. Un nouvel arsenal thérapeutique contre la rhinopneumonie équine. Journées sciences et innovations équines 2020, Nov 2020, Le Pin au Haras, France. ⟨hal-03219395⟩

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2019

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Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Criblage et évaluation de l’effet antiviral de molécules contre les herpèsvirus équins 1 et 4 par la mesure d’impédance cellulaire : effet de la spironolactone. XIIIème journée scientifique Herpes Virus et Pathologies Associées, Mar 2019, Lyon, France. ⟨hal-02286202⟩

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Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Le ganciclovir, pour traiter la rhinopneumonie demain ?. Journées sciences et innovations équines, May 2019, Saumur, France. ⟨hal-02286181⟩

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2018

ref_biblio

Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments (IBCA). IBCA (Impedance-Based Cellular Assays, Jun 2018, Edinburgh, United Kingdom. ⟨hal-02286222⟩

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ref_biblio

Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Effets de l’aciclovir et du ganciclovir contre les herpèsvirus équins : suivi en temps réel par impédancemétrie.. 46èmes journées annuelles de l'Association Vétérinaire Equine Française (AVEF), Nov 2018, Bordeaux, France. ⟨hal-02286392⟩

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Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments. Fourth Havemeyer Equine Herpesvirus Workshop, Oct 2018, Beaufort, United States. ⟨hal-02294033⟩

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2016

ref_biblio

Erika Hue, Christine Fortier, Peggy Suzanne, Aymeric Hans, Stéphan Zientara, et al.. Real-time monitoring of Equid herpesviruses infectivity in equine dermal cell based on impedance measurements. 10th International Equine Infectious Diseases Conference, EIDC, Apr 2016, Buenos Aires, Argentina. pp.S69-S70, ⟨10.1016/j.jevs.2016.02.150⟩. ⟨hal-02273332⟩

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Poster communications

2024

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Camille Victoire Migné, Émilie Quéré, Erika Hue, Margot Begue, Valentine Chaillot, et al.. Antiviral strategies in equines. 12th International Equine Infectious Diseases Conference, Sep 2024, Deauville, France. Equine Vetenary Journal, 56 (Suppl. 60), pp.97-98 (n°159), ⟨10.1111/evj.14215⟩. ⟨hal-04724269⟩

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2021

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Marielle Cochet-Bernoin, François Piumi, Kamila Gorna, Gaelle Gonzalez, Anne Danckaert, et al.. Identification de molécules antivirales contre le virus West Nile par une approche combinant l'imagerie cellulaire et les cellules neurales équines dérivées de cellules souches pluripotentes induites.. XXIIIes Journées Francophones de Virologie, Apr 2021, PARIS, France. ⟨hal-03355907⟩

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ref_biblio

José-Carlos Valle-Casuso, Delphine Gaudaire, A. Madeline, Patrick Dallemagne, Stéphane Pronost, et al.. Purine and pyrimidine biosynthesis inhibitors efficiently suppress equine arteritis virus replication. 11th International Equine Infectious Diseases Conference, Sep 2021, Online, France. Equine veterinary journal, 53 (S56), pp.64-65, 2021, Special Issue: Abstracts of the 11th International Equine Infectious Diseases Conference. ⟨10.1111/evj.97_13495⟩. ⟨hal-03374831⟩

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2019

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Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Criblage et évaluation de l'effet antiviral de molécules contre les herpèsvirus équins 1 et 4 par la mesure d'impédance cellulaire : effet de la spironolactone. XXIème journées francophones de virologie, Mar 2019, Lyon, France. ⟨hal-02286193⟩

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ref_biblio

Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments. Journée des doctorants, 2019, Caen, France. ⟨hal-03454653⟩

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2018

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Côme Thieulent, Erika Hue, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Real-Time monitoring of Equid alphaherpesviruses infectivity in equine dermal cell based on impedance measurements: effects of aciclovir and ganciclovir treatments (poster). IBCA (Impedance-Based Cellular Assays, Jun 2018, Edinburgh, United Kingdom. ⟨hal-02286228⟩

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2017

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Erika Hue, Côme Thieulent, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Impedance monitoring of Equid herpesviruses infectivity in equine dermal cell after acyclovir treatment. 5th Veterinary Herpesvirus Symposium of the European Society For Veterinary Virology (ESVV), Jul 2017, Ghent, Belgium. ⟨hal-02271601⟩

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ref_biblio

Erika Hue, Côme Thieulent, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Suivi en temps réel par impédancemétrie de l'infection des cellules dermiques équines par les herpesvirus équins : effet de l'acyclovir. XIème journées françaises de virologie, Mar 2017, Paris, France. ⟨hal-02294030⟩

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2016

ref_biblio

Erika Hue, Côme Thieulent, Christine Fortier, Peggy Suzanne, Stéphan Zientara, et al.. Real-time monitoring of Equid herpesviruses infectivity in equine dermal cell based on impedance measurements: Effects of acyclovir treatment. 4th Antiviral Congress, Sep 2016, Sitges, France. ⟨hal-02294037⟩

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