Team 1 – Signaling in environmental and drug toxicology

The Team 1 Signaling in environmental and drug toxicology is composed by 2 groups with their own specificities.

Meet Our Specialised Teams

METATOX

Experimental Toxicology

GEMS

Genomic Epidemiology of Multifactorial DiseaseS

METATOX (Experimental toxicology)

Our team identifies the mechanisms of action activated by a variety of environmental pollutants, alone or in combination, to understand their influence on the incidence of various pathologies (cancer, liver diseases, neurodegenerative diseases) in order to identify biomarkers. We use and develop cellular, animal and computational models over several main lines of research:

1) Contextual studies to study the sensitizing effects of persistent organic pollutants such as Seveso dioxin on the development of liver fibrosis or demyelination in the central nervous system. We use rodent models and more recently the nematode C. elegans.

2) We are also developing innovative cell models to study, for example, the influence of adipocytes on tumor metabolic phenotype or the effect of inflammatory cells on hepatocyte function.

3) We leverage our data produced in vivo and in vitro to develop computational models of system toxicology. We develop network biology and predictive toxicology models by integrating these data (into European or national projects) providing potential links between the exposure to environmental chemicals and adverse health outcomes.

4) We host METATOX-HUB PARIS, a technical platform dedicated to the multi-scale study of the toxicity mechanisms of environmental pollutants and drugs.

Keywords: persistent organic pollutants; AhR; metabolic disruption; cancer; chronic liver diseases; computational models

Permanent researchers

Karine Andréau, lecturer, MetaTox
karine.andreau@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 43 62, room P434
Etienne Blanc, Associate professor, MCU Paris Descartes, MetaTox
etienne.blanc@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 43 57, room P434
Sylvie Bortoli, University researcher, IR, MetaTox
sylvie.bortoli@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 43 75, room P461
Caroline Chauvet, Associate Professor, MetaTox
caroline.chauvet@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 43 76, room P433
Xavier Coumoul, University Professor, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, MetaTox
xavier.coumoul@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 43 56, room P433
Jules IMLER, Engineer Université Paris Cité, MetaTox
Meriem Koual, Associate professor, MCU-PH, MetaTox
Marie-Aude Le Frere-Belda, University Professor, MetaTox
marie-aude.le-frere-belda@-Code to remove to avoid SPAM-aphp.fr
Fabrice Lecuru, University Professor, MetaTox
fabrice.lecuru@-Code to remove to avoid SPAM-egp.aphp.fr
Philippe Noirez, Associate professor, MCU Paris Descartes, MetaTox
philippe.noirez@-Code to remove to avoid SPAM-u-paris.fr
Evelyne Segal, INSERM researcher, DR-INSERM, Cellular homeostasis and cancer, MetaTox
evelyne.segal-bendirdjian@-Code to remove to avoid SPAM-inserm.fr
Kajanan SIVAKUMAR, INSERM Engineer, MetaTox
Nadia Soussi-Yanicostas, PhD Directrice de Recherche (DR1) au CNRS, MetaTox
Nicolas Stadler, INSERM Engineer, Cellular homeostasis and cancer, MetaTox
nicolas.stadler@-Code to remove to avoid SPAM-inserm.fr
Jacqueline Varennes, Technician, , MetaTox
jacqueline.varennes@-Code to remove to avoid SPAM-inserm.fr

Support staff

Estelle Lecat, Assistant Engineer, MetaTox, Systox
Sylvia Sanquer, AP-HP, MetaTox
Arnaud Tête, Senior Engineer, METATOX-HUB PARIS, MetaTox
arnaud.tete@-Code to remove to avoid SPAM-u-paris.fr
Céline Tomkiewicz-Raulet, INSERM Engineer, MetaTox
Celine.Tomkiewicz-raulet@-Code to remove to avoid SPAM-u-paris.fr, +33 1 76 53 43 55, room P431

Post docs and PhD students

Lucas GAILLARD, PhD student, MetaTox

GEMS (Genomic Epidemiology of Multifactorial DiseaseS)

The GEMS group develops statistical methods and strategies in genomic epidemiology to identify genes and gene-exposome interactions involved in multifactorial diseases (asthma, allergic diseases, melanoma). This research program integrates multi-omics data (genomics, epigenomics, transcriptomics, metabolomics) together with biological knowledge, through pathway and network analyses, to provide further insight into the molecular mechanisms involved in the disease process.

Keywwords: Genome-wide association studies, gene-environment interactions, statistical genetics, software development, integration of omics, asthma, allergic diseases, melanoma

Permanent researchers

Claudia BEJAR, APHP - PH, Genomic Epidemiology of Multifactorial DiseaseS
Emmanuelle Bouzigon, INSERM researcher, CR- INSERM, Genomic Epidemiology of Multifactorial DiseaseS
emmanuelle.bouzigon@-Code to remove to avoid SPAM-inserm.fr
Florence Demenais, INSERM researcher, DR- INSERM, Genomic Epidemiology of Multifactorial DiseaseS
florence.demenais@-Code to remove to avoid SPAM-inserm.fr
Eve Maubec, University Professor, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Genomic Epidemiology of Multifactorial DiseaseS
eve.maubec@-Code to remove to avoid SPAM-inserm.fr

Support staff

Jessica MARTINEZ, APHP - ISP, Genomic Epidemiology of Multifactorial DiseaseS
Lucie TROUBAT, INSERM Engineer, Genomic Epidemiology of Multifactorial DiseaseS

Post docs and PhD students

Pradeep ERANTI, Doctoral Student, Genomic Epidemiology of Multifactorial DiseaseS
Haibo HUANG, Doctoral Student, Genomic Epidemiology of Multifactorial DiseaseS
Sofia TZOUMPA, Master Student, Genomic Epidemiology of Multifactorial DiseaseS
Raphaël VERNET, Doctoral Student, Genomic Epidemiology of Multifactorial DiseaseS