Team 3 – Myelination and Nervous system pathologies

Despite the severe impact of the diseases of demyelination on patients’ lives and society, little is known about the processes of de/re/myelination. Our aim is to build a research group working on myelin physiology and pathologies affecting the nervous system. The main focuses are: (i) to identify new signaling pathways involved in myelination and demyelination; (ii) to examine their impact on nervous system pathologies (Multiple Sclerosis [MS], Nerve Injuries, Diabetic Peripheral Neuropathies [DPN], Traumatic Brain Injuries [TBI]); (iii) to study the impact of the environmental factors (stress, pollutants) on normal myelination process and on enhancing insults to cause exacerbated demyelination and co-morbidity.

We will develop an interdisciplinary research based on preclinical and clinical approaches using molecular and cell biology, behavior, biophysics and physiology to study the myelination process as well as de/remyelination following pathological conditions. We will focus our work on oxysterol/LXR, dioxin/AhR and ADAM10 pathways as well as oxidative stress. Our project will allow deciphering the signaling pathways involved in myelination process and their dysregulation during demyelination. It will also open new avenues for the treatment of myelin pathologies.

Permanent researchers

Céline Becker, Assistant Engineer, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Myelination and Nervous system pathologies
celine.becker@-Code to remove to avoid SPAM-inserm.fr, room H330
Christel Becker, Associate professor, MCU Paris Descartes, Myelination and Nervous system pathologies
christel.becker@-Code to remove to avoid SPAM-u-paris.fr
Jean-Jacques Benoliel, Associate professor, MCU-PH Paris Descartes, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Myelination and Nervous system pathologies
jean-jacques.benoliel@-Code to remove to avoid SPAM-upmc.fr, room H344
Sophie Bernard, University Professor, Myelination and Nervous system pathologies
sophie.bernard@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 20 46, room H344 A
Franck Brouillard, Associate professor, MCU Paris Descartes, Myelination and Nervous system pathologies
franck.brouillard@-Code to remove to avoid SPAM-inserm.fr, room H344
Julien Grenier, Associate professor, MCU Paris Descartes, Cell death in host-pathogen interactions, Myelination and Nervous system pathologies
julien.grenier@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 38 87, room H330
Mehrnaz Jafarian-Tehrani, University Professor, Myelination and Nervous system pathologies
mehrnaz.jafarian-tehrani@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 99 76, room H330
Damien Le Menuet, INSERM researcher, CR- INSERM, Myelination and Nervous system pathologies
damien.le-menuet@-Code to remove to avoid SPAM-inserm.fr, +33 1 70 64 99 76, room H330
Charbel Massaad, university Professor, Genetic Epidemiology and functional Genomics of Multifactorial Diseases, Myelination and Nervous system pathologies
charbel.massaad@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 22 22, room P410
Delphine Meffre, Associate professor, MCU Paris Descartes, Europe department, Myelination and Nervous system pathologies
delphine.meffre@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 22 73, room H344
Hugo Salmon, Assistant Professor, Cell death in host-pathogen interactions, Myelination and Nervous system pathologies
hugo.salmon@-Code to remove to avoid SPAM-u-paris.fr

Support staff

Anne Simon, Engineer, Myelination and Nervous system pathologies
anne.simon@-Code to remove to avoid SPAM-u-paris.fr, +33 1 42 86 21 53 or 38 87, room H330

Post docs and PhD students

Pilar ACEBO, PhD student, Myelination and Nervous system pathologies
Sara FALGHERA, PhD student, Myelination and Nervous system pathologies
Mathis LAVAUD, PhD student, Myelination and Nervous system pathologies

Journal articles

2024

ref_biblio
Aïda Padilla-Ferrer, Alex Carrete, Anne Simon, Delphine Meffre, Mehrnaz Jafarian-Tehrani. A Disintegrin And Metalloprotease 10 expression within the murine central nervous system. Brain Research, 2024, 1834, pp.148888. ⟨10.1016/j.brainres.2024.148888⟩. ⟨hal-04595759⟩

Accès au texte intégral et bibtex

2023

ref_biblio
Alberto González-Mayoral, Axel Eid, Razmig Derounian, Virginia Sofia Campanella, Andreia da Silva Ramos, et al.. Mineralocorticoid receptor knockout in Schwann cells alters myelin sheath thickness. Journal of Endocrinology, 2023, 258 (2), pp.e220334. ⟨10.1530/JOE-22-0334⟩. ⟨inserm-04163081⟩

Accès au texte intégral et bibtex

2021

ref_biblio
Jérémie Canonica, Min Zhao, Tatiana Favez, Emmanuelle Gelizé, Laurent Jonet, et al.. Pathogenic Effects of Mineralocorticoid Pathway Activation in Retinal Pigment Epithelium. International Journal of Molecular Sciences, 2021, 22 (17), pp.9618. ⟨10.3390/ijms22179618⟩. ⟨hal-03353932⟩

Accès au texte intégral et bibtex

2019

ref_biblio
Hui Chen, Larbi Amazit, Marc Lombès, Damien Le Menuet. Crosstalk Between Glucocorticoid Receptor and Early-growth Response Protein 1 Accounts for Repression of Brain-derived Neurotrophic Factor Transcript 4 Expression. Neuroscience, 2019, 399, pp.12-27. ⟨10.1016/j.neuroscience.2018.12.012⟩. ⟨inserm-02298752⟩

Accès au texte intégral et bibtex

ref_biblio
Emmanuelle Kuhn, Khadija Lamribet, Say Viengchareun, Damien Le Menuet, Bruno Fève, et al.. UCP1 transrepression in Brown Fat in vivo and mineralocorticoid receptor anti-thermogenic effects. Annales d'Endocrinologie = Annals of Endocrinology, 2019, 80 (1), pp.1-9. ⟨10.1016/j.ando.2018.04.018⟩. ⟨hal-02189371⟩

Accès au texte intégral et bibtex

ref_biblio
Gemma Llufriu-Dabén, Delphine Meffre, Charbel Massaad, Mehrnaz Jafarian-Tehrani. A novel model of trauma-induced cerebellar injury and myelin loss in mouse organotypic cerebellar slice cultures using live imaging. Journal of Neuroscience Methods, 2019, 311, pp.385-393. ⟨10.1016/j.jneumeth.2018.09.023⟩. ⟨hal-04914348⟩

Accès au bibtex

2018

ref_biblio
Elena Chierto, Anne Simon, Francesca Castoldi, Delphine Meffre, Giulia Cristinziano, et al.. Mechanical Stretch of High Magnitude Provokes Axonal Injury, Elongation of Paranodal Junctions, and Signaling Alterations in Oligodendrocytes. Molecular Neurobiology, 2018, 56 (6), pp.4231-4248. ⟨10.1007/s12035-018-1372-6⟩. ⟨hal-04914110⟩

Accès au bibtex

2017

ref_biblio
Hui Chen, Marc Lombès, Damien Le Menuet. Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells. Molecular Brain, 2017, 10 (1), pp.12. ⟨10.1186/s13041-017-0295-x⟩. ⟨inserm-02329880⟩

Accès au texte intégral et bibtex

2014

ref_biblio
Emmanuelle Kuhn, Christine Bourgeois, Vixra Keo, Say Viengchareun, Adeline Muscat, et al.. Paradoxical resistance to high fat diet-induced obesity and altered macrophage polarization in mineralocorticoid receptor overexpressing mice.. AJP - Endocrinology and Metabolism, 2014, 306 (1), pp.E75-90. ⟨10.1152/ajpendo.00323.2013⟩. ⟨inserm-00911857⟩

Accès au texte intégral et bibtex

2013

ref_biblio
Laetitia Martinerie, Mathilde Munier, Damien Le Menuet, Geri Meduri, Say Viengchareun, et al.. The mineralocorticoid signaling pathway throughout development: Expression, regulation and pathophysiological implications. Biochimie, 2013, 95 (2), pp.148-157. ⟨10.1016/j.biochi.2012.09.030⟩. ⟨hal-02955448⟩

Accès au texte intégral et bibtex

2012

ref_biblio
Damien Le Menuet, Mathilde Munier, Giulia Campostrini, Marc Lombès. Mineralocorticoid receptor and embryonic stem cell models: Molecular insights and pathophysiological relevance. Molecular and Cellular Endocrinology, 2012, 350 (2), pp.216-222. ⟨10.1016/j.mce.2011.06.036⟩. ⟨hal-02955447⟩

Accès au bibtex

ref_biblio
Mathilde Munier, Fredéric Law, Géri Meduri, Damien Le Menuet, Marc Lombes. Mineralocorticoid receptor overexpression facilitates differentiation and promotes survival of embryonic stem cell-derived neurons.. Endocrinology, 2012, 153 (3), pp.1330-40. ⟨10.1210/en.2011-1436⟩. ⟨inserm-00654278⟩

Accès au texte intégral et bibtex

2010

ref_biblio
Damien Le Menuet, Mathilde Munier, Géri Meduri, Say Viengchareun, Marc Lombès. Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.. Cardiovascular Research, 2010, 87 (3), pp.467-75. ⟨10.1093/cvr/cvq087⟩. ⟨inserm-00463814⟩

Accès au texte intégral et bibtex

ref_biblio
Mathilde Munier, Geri Meduri, Say Viengchareun, Phillipe Leclerc, Damien Le Menuet, et al.. Regulation of mineralocorticoid receptor expression during neuronal differentiation of murine embryonic stem cells.. Endocrinology, 2010, 151 (5), pp.2244-54. ⟨10.1210/en.2009-0753⟩. ⟨inserm-00450814⟩

Accès au texte intégral et bibtex

2007

ref_biblio
Say Viengchareun, Damien Le Menuet, Laetitia Martinerie, Mathilde Munier, Laurent Pascual-Le Tallec, et al.. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.. Nuclear Receptor Signaling, 2007, 5, pp.e012. ⟨10.1621/nrs.05012⟩. ⟨inserm-00193515⟩

Accès au texte intégral et bibtex